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Balance Sheet Components - Additional Information (Detail) | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2019 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2019 USD ($) Milestone | Sep. 30, 2018 USD ($) | Dec. 31, 2018 USD ($)
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Cash and cash equivalents | $ 196,592,000 |  | $ 196,592,000 |  | $ 89,258,000
Contractual maturities of available-for-sale investments |  |  | 1 year |  |
Other-than-temporary impairment loss | 0 | $ 0 | $ 0 | $ 0 |
Provision to write-down excess and obsolete inventory | 0 |  | $ 0 |  |
Number of regulatory milestones | Milestone |  |  | 2 |  |
Unbilled contract assets | 180,000,000 |  | $ 180,000,000 |  | 0
Building shell cost | 142,310,000 |  | 142,310,000 |  | 192,397,000
Accumulated depreciation | 99,102,000 |  | 99,102,000 |  | 65,199,000
Building shell [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Building shell cost | 0 |  | 0 |  | 53,880,000
Building [Member] | Build to suit arrangements [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Accumulated depreciation |  |  |  |  | 13,500,000
Leasehold improvements [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Building shell cost | 101,339,000 |  | 101,339,000 |  | 101,200,000
Leasehold improvements [Member] | Accounting standards update 2016-02 [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Accumulated depreciation | 38,900,000 |  | 38,900,000 |  |
Europe [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Unbilled contract assets | 130,000,000.0 |  | 130,000,000.0 |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Unbilled contract assets | 130,000,000.0 |  | 130,000,000.0 |  |
AstraZeneca Agreements [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Unbilled contract assets | 50,000,000.0 |  | 50,000,000.0 |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Unbilled contract assets | 50,000,000.0 |  | 50,000,000.0 |  |
Foreign subsidiaries [Member] |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |
Cash and cash equivalents | $ 18,100,000 |  | $ 18,100,000 |  | $ 21,900,000

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