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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 9 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended
--- | --- | --- | --- | --- | ---
Sep. 30, 2019 | Apr. 30, 2006 | Jun. 30, 2005 | Sep. 30, 2019 | Dec. 31, 2018 | Feb. 28, 2009 | Feb. 28, 2009
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Unbilled contract asset | $ 180,000 |  |  | $ 180,000 | $ 0 |  |
Europe [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Unbilled contract asset | 130,000 |  |  | 130,000 |  |  |
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  | $ 40,100
Potential milestone payments | 12,500 |  | $ 132,500 |  |  |  |
Commercial sales milestone |  |  | 15,000 |  |  |  |
Aggregate consideration received | 77,600 |  |  | 77,600 |  |  |
Transaction price and allocated to performance obligations | 12,500 |  |  | 12,500 |  |  |
Astellas Agreement [Member] | Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 22,500 |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 95,000 |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  | $ 320,000 |
Potential milestone payments |  | $ 425,000 |  |  |  |  |
Aggregate consideration received | 410,000 |  |  | 410,000 |  |  |
Transaction price and allocated to performance obligations | 130,000 |  |  | $ 130,000 |  |  |
Percentage of joint development costs committed to fund |  | 50.00% |  |  |  |  |
Additional consideration based on net sales description |  |  |  | low 20% range |  |  |
Estimated joint development extended service period |  |  |  |  | 2023 |  |
Revenue during period from performance obligations | 129,000 |  |  | $ 129,000 |  |  |
Unbilled contract asset | $ 130,000 |  |  | $ 130,000 |  |  |
Astellas Agreement [Member] | Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  | $ 90,000 |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  | $ 335,000 |  |  |  |  |

X
- Definition The amount of additional consideration based on net sales of product as defined under a collaboration agreement. + References No definition available. + Details
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X
- Definition Amount of aggregate consideration receivable under collaborative arrangement. + References No definition available. + Details
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X
- Definition Represents the amount of milestone payments related to commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Estimated joint development extended service period. + References No definition available. + Details
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- Definition Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs. + References No definition available. + Details
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- Definition Represents the total potential amount of milestone payments related to development, regulatory approval and commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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