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Collaboration Agreements - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  |  |  | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 29, 2018 | Dec. 17, 2018 | Jul. 30, 2013 | Sep. 30, 2019 | Dec. 31, 2015 | Jun. 30, 2019 | Dec. 31, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Unbilled contract asset |  |  |  | $ 180,000 |  |  | $ 0
AstraZeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Transaction price and allocated to performance obligations |  |  |  |  |  | $ 50,000 |
Revenue during period from performance obligations |  |  |  | 42,100 |  |  |
Unbilled contract asset |  |  |  | 50,000 |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments |  |  | $ 374,000 |  |  |  |
Potential milestone payments |  |  | 875,000 |  |  |  |
Commercial sales milestone |  |  | 325,000 |  |  |  |
Aggregate consideration received |  |  |  | 389,000 |  |  |
Unbilled contract asset |  |  |  | 50,000 |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 65,000 |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 325,000 |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Deferred Approval Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 160,000 |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Development Milestones [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Receipt of development milestone payment |  |  |  |  | $ 15,000 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 348,500 |  |  |  |
Aggregate consideration received |  |  |  | $ 55,200 |  |  |
Proceeds from upfront, non-contingent and non-refundable payments |  |  | 28,200 |  |  |  |
Commercial sales and other events milestone |  |  | 187,500 |  |  |  |
Estimated joint development extended service period |  |  |  | 2024 |  |  |
Milestone payment, revenue recognition | $ 6,000 | $ 6,000 |  |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | 15,000 |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 146,000 |  |  |  |

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