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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Revenue:        
Total revenue $ 33,174 $ 29,027 $ 248,603 $ 104,903
Operating costs and expenses:        
Cost of goods sold $ 242 $ 0 $ 242 $ 0
Cost, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Research and development $ 49,963 $ 56,443 $ 152,467 $ 165,555
Selling, general and administrative 35,823 15,356 84,772 45,961
Total operating costs and expenses 86,028 71,799 237,481 211,516
Income (loss) from operations (52,854) (42,772) 11,122 (106,613)
Interest and other, net        
Interest expense (702) (2,739) (2,209) (8,257)
Interest income and other, net 4,193 3,079 12,496 7,796
Total interest and other, net 3,491 340 10,287 (461)
Income (loss) before income taxes (49,363) (42,432) 21,409 (107,074)
Provision for income taxes 76 124 256 299
Net income (loss) $ (49,439) $ (42,556) $ 21,153 $ (107,373)
Net income (loss) per share:        
Basic $ (0.57) $ (0.50) $ 0.24 $ (1.28)
Diluted $ (0.57) $ (0.50) $ 0.23 $ (1.28)
Weighted average number of common shares used to calculate net income (loss) per share:        
Basic 87,007 84,508 86,390 83,713
Diluted 87,007 84,508 91,995 83,713
License Revenue [Member]        
Revenue:        
Total revenue $ 11,935 $ 0 $ 162,517 $ 14,323
Development and Other Revenue [Member]        
Revenue:        
Total revenue 20,660 29,027 85,507 90,580
Product Revenue [Member]        
Revenue:        
Total revenue $ 579 $ 0 $ 579 $ 0