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Related Party Transactions - Additional Information (Detail) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Related Party Transaction [Line Items]
Accounts receivable from related party	$ 17,662,000		$ 17,662,000		$ 47,210,000
Accrued liabilities to related party	954,000		954,000		444,000
Unbilled contract asset	180,000,000		180,000,000		0
Due from Related Parties, Current	126,012,000		126,012,000		0
Net unbilled contract asset	126,012,000		126,012,000		0
Deferred Revenue	53,988,000		53,988,000		0
Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Astellas Agreement [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Deferred Revenue	3,988,000		3,988,000
Astellas [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Net unbilled contract asset	126,000,000.0		126,000,000.0
Deferred Revenue	4,000,000.0		4,000,000.0
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	15,500,000	$ 5,100,000	155,000,000.0	$ 30,800,000
Expense related to collaboration agreements	900,000	$ 400,000	2,200,000	$ 1,100,000
Accounts receivable from related party	17,700,000		17,700,000		47,200,000
Accrued liabilities to related party	1,700,000		1,700,000		400,000
Astellas [Member] | Astellas Agreement [Member] | Milestone Payment [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party	$ 12,500,000		$ 12,500,000
Astellas [Member] | Astellas Agreement [Member] | Active Pharmaceutical Ingredients Shipment [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party					$ 43,800,000

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