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Collaboration Agreements and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended
--- | --- | --- | --- | --- | --- | ---
Nov. 30, 2018 | Sep. 30, 2019 | Dec. 31, 2018 | Apr. 30, 2006 | Jun. 30, 2005 | Jun. 30, 2018 | Dec. 31, 2019 | Feb. 28, 2009 | Feb. 28, 2009
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Unbilled contract asset |  |  | $ 0 |  |  |  | $ 180,000 |  |
Europe [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Unbilled contract asset |  |  |  |  |  |  | $ 130,000 |  |
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  |  | $ 40,100
Potential milestone payments |  | $ 12,500 |  |  | $ 132,500 |  |  |  |
Commercial sales milestone |  |  |  |  | 15,000 |  |  |  |
Additional consideration based on net sales description |  |  |  |  |  |  | low 20% range |  |
Aggregate consideration received |  |  |  |  |  |  | $ 90,100 |  |
Transaction price and allocated to performance obligations |  | $ 12,500 |  |  |  |  |  |  |
Consideration associated with milestone included in transaction price |  |  |  |  |  | $ 15,000 |  |  |
Contract with customer, liability, revenue recognized |  |  | $ 43,900 |  |  | $ 20,900 |  |  |
Difference in estimated and actual listed price | $ 36,300 |  |  |  |  |  | $ 36,300 |  |
Astellas Agreement [Member] | Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  | 22,500 |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  | $ 95,000 |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  | $ 320,000 |
Additional consideration based on net sales description |  |  |  |  |  |  | low 20% range |  |
Aggregate consideration received |  |  |  |  |  |  | $ 410,000 |  |
Transaction price and allocated to performance obligations |  |  |  |  |  |  | 130,000 |  |
Development and regulatory approval milestones |  |  |  | $ 425,000 |  |  |  |  |
Percentage of joint development costs committed to fund |  |  |  | 50.00% |  |  |  |  |
Revenue during period from performance obligations |  |  |  |  |  |  | 128,800 |  |
Unbilled contract asset |  |  |  |  |  |  | $ 130,000 |  |
Estimated joint development extended service period |  |  |  |  |  |  | 2023 |  |
Astellas Agreement [Member] | Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  | $ 90,000 |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  | $ 335,000 |  |  |  |  |

X
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