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v3.19.3.a.u2

Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Other Comprehensive Loss [Member] | Accumulated Deficit [Member] | Noncontrolling Interests [Member]
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ 135,069 | $ 637 | $ 625,903 | $ (960) | $ (509,782) | $ 19,271
Balance, Shares at Dec. 31, 2016 |  | 63,665,284 |  |  |  |
Net loss | (120,875) | $ 0 | 0 | 0 | (120,875) | 0
Change in unrealized gain or loss on investments | 1,187 | 0 | 0 | 1,187 | 0 | 0
Foreign currency translation adjustments | (2,022) | 0 | 0 | (2,022) | 0 | 0
Follow-on Offerings, net of underwriting discounts, commission and issuance costs | 470,226 | $ 144 | 470,082 | 0 | 0 | 0
Follow-on Offerings, net of underwriting discounts, commission and issuance costs, Shares |  | 14,428,750 |  |  |  |
Shares issued from stock plans, net of payroll taxes paid | 26,614 | $ 44 | 26,570 | 0 | 0 | 0
Shares issued from stock plans, net of payroll taxes paid, Shares |  | 4,404,094 |  |  |  |
Stock-based compensation | 37,539 | $ 0 | 37,539 | 0 | 0 | 0
Balance at Dec. 31, 2017 | 547,738 | $ 825 | 1,160,094 | (1,795) | (630,657) | 19,271
Balance, Shares at Dec. 31, 2017 |  | 82,498,128 |  |  |  |
Impact of change in accounting principle upon adoption | ASU 2016-01 [Member] | 0 | $ 0 | 0 | (1,250) | 1,250 | 0
Net loss | (86,420) | 0 | 0 | 0 | (86,420) | 0
Change in unrealized gain or loss on investments | (7) | 0 | 0 | (7) | 0 | 0
Foreign currency translation adjustments | 771 | 0 | 0 | 771 | 0 | 0
Adjustment to issuance costs for Follow-on Offerings | 11 | 0 | 11 | 0 | 0 | 0
Shares issued from stock plans, net of payroll taxes paid | 14,235 | $ 29 | 14,206 | 0 | 0 | 0
Shares issued from stock plans, net of payroll taxes paid, Shares |  | 2,933,974 |  |  |  |
Stock-based compensation | 52,142 | $ 0 | 52,142 | 0 | 0 | 0
Balance at Dec. 31, 2018 | 528,470 | $ 854 | 1,226,453 | (2,281) | (715,827) | 19,271
Balance, Shares at Dec. 31, 2018 |  | 85,432,102 |  |  |  |
Impact of change in accounting principle upon adoption | ASU 2016-02 [Member] | 8,688 | $ 0 | 0 | 0 | 8,688 | 0
Impact of change in accounting principle upon adoption | ASU 2018-02 [Member] | 0 | 0 | 0 | 611 | (611) | 0
Net loss | (76,970) | 0 | 0 | 0 | (76,970) | 0
Change in unrealized gain or loss on investments | 592 | 0 | 0 | 592 | 0 | 0
Foreign currency translation adjustments | 331 | 0 | 0 | 331 | 0 | 0
Shares issued from stock plans, net of payroll taxes paid | 7,962 | $ 23 | 7,939 | 0 | 0 | 0
Shares issued from stock plans, net of payroll taxes paid, Shares |  | 2,220,957 |  |  |  |
Warrants exercised | 66 | $ 0 | 66 | 0 | 0 | 0
Warrants exercised, Shares |  | 4,430 |  |  |  |
Stock-based compensation | 66,267 | $ 0 | 66,267 | 0 | 0 | 0
Balance at Dec. 31, 2019 | $ 535,406 | $ 877 | $ 1,300,725 | $ (747) | $ (784,720) | $ 19,271
Balance, Shares at Dec. 31, 2019 |  | 87,657,489 |  |  |  |

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