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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Operating activities |  |  |
Net loss | $ (76,970) | $ (86,420) | $ (120,875)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 11,147 | 6,562 | 6,099
Amortization of finance lease right-of-use assets | 10,307 | 0 | 0
Net amortization (accretion) of premium (discount) on investments | (3,667) | (42) | 1,844
Unrealized loss (gain) on cash equivalents and short-term equity investments | (88) | 1,120 | 2
Loss (gain) on disposal of property and equipment | (42) | 53 | 3
Stock-based compensation | 66,267 | 52,142 | 37,539
Realized foreign currency gain | 0 | (1,074) | 0
Realized gain on sales of available-for-sale securities | 0 | (87) | (143)
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net ($42,365, $(43,486) and $98 from a related party) | 35,229 | (55,232) | 1,996
Inventories | (6,887) | 0 | 0
Prepaid expenses and other current assets ($(125,210), $0 and $0 from a related party) | (128,598) | (129) | (1,911)
Other assets | (3,253) | 1,090 | (2,365)
Accounts payable | (3,051) | 3,630 | (714)
Accrued and other liabilities ($36,439, $172 and $(1,343) from a related party) | 18,288 | 5,606 | 9,196
Deferred revenue | (49,941) | (5,031) | 174
Lease obligations | 0 | 32 | 1,023
Accrued interest for finance lease liabilities | 194 | 0 | 0
Other long-term liabilities | 52,360 | 1,636 | 1,619
Net cash used in operating activities | (78,705) | (76,144) | (66,513)
Investing activities |  |  |
Purchases of property and equipment | (5,762) | (8,020) | (8,500)
Proceeds from sale of property and equipment | 7 | 184 | 5
Purchases of available-for-sale securities and term deposit | (411,299) | (576,880) | (169)
Proceeds from sales of available-for-sale securities | 0 | 8,167 | 21,109
Proceeds from maturities of investments | 537,072 | 54,426 | 57,421
Net cash provided by (used in) investing activities | 120,018 | (522,123) | 69,866
Financing activities |  |  |
Borrowings under capital lease obligations | 0 | 49 | 0
Repayments of capital lease obligations | 0 | (6) | 0
Repayments of finance lease liabilities | (11,925) | 0 | 0
Repayments of lease obligations | (403) | (403) | (403)
Proceeds from follow-on offerings, net of underwriting discounts and commission costs | 0 | 0 | 471,205
Cash paid for payroll taxes on restricted stock unit releases | (12,750) | (15,612) | (8,296)
Proceeds from issuance of common stock | 20,778 | 29,847 | 34,910
Payments of deferred offering costs | 0 | 0 | (944)
Net cash provided by (used in) financing activities | (4,300) | 13,875 | 496,472
Effect of exchange rate change on cash and cash equivalents | (5) | (8) | 51
Net increase (decrease) in cash and cash equivalents | 37,008 | (584,400) | 499,876
Total cash and cash equivalents at beginning of period | 89,258 | 673,658 | 173,782
Total cash and cash equivalents at end of period | 126,266 | 89,258 | 673,658
Supplemental cash flow information: |  |  |
Interest payments | 174 | 218 | 255
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 460 | 276 | 3,781
Deferred offering costs recorded in accounts payable and accrued liabilities | $ 0 | $ 24 | $ 35

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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow from proceeds received from lessor related to a long-term capital lease obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the sale, maturity and collection of all investments such as debt, security and so forth during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26853-111562 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118930883&loc=SL7669619-108580 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1B -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118930883&loc=SL7669625-108580 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599 Reference 6: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=116874947&loc=SL4591551-111686 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3000-108585 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=108774443&loc=SL4569616-111683 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8933-108599 Reference 10: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=116874947&loc=SL4591552-111686 + Details
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- Definition Amount of cash outflow for short-term and long-term debt and lease obligation. + References No definition available. + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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