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Collaboration Agreements and Revenues - Accounting for the Astellas Agreements - Additional Information 2 (Detail) | 12 Months Ended
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Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Manufacturing commercial supplies of products, revenue recognized | $ 256,577,000 | $ 212,958,000 | $ 130,996,000
Astellas Agreement [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Co-development services, currently estimated continuation year | 2023 |  |
Astellas Agreement [Member] | Manufacturing Commercial Supplies of Products [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Manufacturing commercial supplies of products, revenue recognized | $ 0 |  |
Astellas Agreement [Member] | Minimum [Member] | Measurement Input Discount Rate [Member] | Discounted Cash Flow [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Discount rate applied | 17.5 |  |
Astellas Agreement [Member] | Maximum [Member] | Measurement Input Discount Rate [Member] | Discounted Cash Flow [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Discount rate applied | 20.0 |  |
Astellas Agreement [Member] | Japan [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Non-contingent upfront payments received | $ 40,100,000 |  |
Variable consideration related to payments for milestones considered probable of being achieved | 50,000,000.0 |  |
Variable consideration related to co-development billings | 11,400,000 |  |
Provision for co-development services | 0 |  |
Astellas Agreement [Member] | Europe [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Non-contingent upfront payments received | 320,000,000.0 |  |
Variable consideration related to payments for milestones considered probable of being achieved | 220,000,000.0 |  |
Variable consideration related to co-development billings | $ 229,200,000 |  |

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