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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2019

Accounting Policy [Line Items]

Schedule of Significant Balance of Accounts Receivable

The Company has not experienced any loss on its deposits of cash and cash equivalents. Included in current assets are significant balances of accounts receivable as follows:

		December 31,
		2019				2018
Astellas Pharma Inc. (“Astellas”)—Related party			17	%			74	%
AstraZeneca AB (“AstraZeneca”)			81	%			26	%

ASU 2016-02 [Member]

Accounting Policy [Line Items]

Schedule of Impacts Upon Adoption of New Guidance

The impacts to the select line items from the Company’s consolidated balance sheet upon adoption of the ASC 842 guidance are as follows (in thousands):

Balance Sheet Line Item		Nature of Adjustment		New Lease Guidance Adoption Adjustment
Assets
Property and equipment, net		Derecognition - build-to-suit lease assets - building shell, cost		$	(53,880	)
		Derecognition - build-to-suit lease assets - building shell,     accumulated depreciation			13,476
		Change of useful life - leasehold improvements,     accumulated depreciation			(38,877	)
Finance lease right-of-use assets		Recognition - finance lease ROU assets			49,597
Other assets		Recognition - operating lease ROU assets			730
Liabilities
Accrued and other current liabilities		Derecognition - deferred rent, current			(619	)
		Derecognition - build-to-suit lease liabilities, current			(545	)
		Recognition - operating lease liabilities, current			404
Finance lease liabilities, current		Recognition - finance lease liabilities, current			11,499
Long-term portion of lease obligations		Derecognition - build-to-suit lease liabilities, non-current			(95,613	)
Deferred rent		Derecognition - deferred rent, non-current			(3,038	)
Finance lease liabilities, non-current		Recognition - finance lease liabilities, non-current			49,884
Other long-term liabilities		Recognition - operating lease liabilities, non-current			250
Stockholders’ equity
Accumulated deficit		Cumulative decrease to accumulated deficit		$	8,688

ASU 2018-02 [Member]

Accounting Policy [Line Items]

Schedule of Impacts Upon Adoption of New Guidance

The impacts, based on the aggregate portfolio approach, to the Company’s accumulated other comprehensive loss and accumulated deficit upon adoption of this guidance are as follows (in thousands):

		Accumulated Other Comprehensive Loss				Accumulated Deficit
Balance at December 31, 2018		$	(2,281	)		$	(715,827	)
Impact of change in accounting principle    upon adoption of ASU 2018-02			611				(611	)
Opening balance as of January 1, 2019		$	(1,670	)		$	(716,438	)

ASU 2016-01 [Member]

Accounting Policy [Line Items]

Schedule of Impacts Upon Adoption of New Guidance

The impacts to the Company’s accumulated other comprehensive loss and accumulated deficit upon adoption of this guidance are as follows (in thousands):

		Accumulated Other Comprehensive Loss				Accumulated Deficit
Balance at December 31, 2017		$	(1,795	)		$	(630,657	)
Impact of change in accounting principle    upon adoption of ASU 2016-01			(1,250	)			1,250
Opening balance as of January 1, 2018		$	(3,045	)		$	(629,407	)

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