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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Revenue:      
Total revenue $ 256,577 $ 212,958 $ 130,996
Operating costs and expenses:      
Cost of goods sold $ 1,147 $ 0 $ 0
Cost, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Research and development $ 209,265 $ 235,839 $ 196,517
Selling, general and administrative 135,479 63,812 51,760
Total operating costs and expenses 345,891 299,651 248,277
Loss from operations (89,314) (86,693) (117,281)
Interest and other, net      
Interest expense (2,876) (10,991) (9,706)
Interest income and other, net 15,548 11,568 6,433
Total interest and other, net 12,672 577 (3,273)
Loss before income taxes (76,642) (86,116) (120,554)
Provision for income taxes 328 304 321
Net loss $ (76,970) $ (86,420) $ (120,875)
Net loss per share - basic and diluted $ (0.89) $ (1.03) $ (1.66)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 86,633 84,062 72,987
License Revenue [Member]      
Revenue:      
Total revenue $ 177,086 $ 22,269 $ 9,933
Development and Other Revenue [Member]      
Revenue:      
Total revenue 114,115 125,913 121,063
Product Revenue [Member]      
Revenue:      
Total revenue $ (34,624) $ 64,776 $ 0