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Balance Sheet Components - Additional Information (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2019 USD ($) Milestone	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Jan. 01, 2019 USD ($)
Schedule of Available-for-sale Securities [Line Items]
Number of regulatory milestones | Milestone	2
Unbilled contract assets	$ 180,000	$ 0
Building shell cost	143,107	192,397
Accumulated depreciation	100,364	65,199
Depreciation expense	11,147	6,562	$ 6,099
API product price change in estimated variable consideration	36,324	0
Accrued long-term co-promotional expenses	53,071	0
Building shell [Member]
Schedule of Available-for-sale Securities [Line Items]
Building shell cost	0	53,880
Building [Member] | Build to suit arrangements [Member]
Schedule of Available-for-sale Securities [Line Items]
Accumulated depreciation		13,500
Leasehold improvements [Member]
Schedule of Available-for-sale Securities [Line Items]
Building shell cost	101,548	$ 101,200
Leasehold improvements [Member] | Accounting standards update 2016-02 [Member]
Schedule of Available-for-sale Securities [Line Items]
Accumulated depreciation				$ 38,900
Europe [Member]
Schedule of Available-for-sale Securities [Line Items]
Unbilled contract assets	130,000
Astellas Agreement [Member] | Europe [Member]
Schedule of Available-for-sale Securities [Line Items]
Unbilled contract assets	130,000
AstraZeneca Agreements [Member]
Schedule of Available-for-sale Securities [Line Items]
Unbilled contract assets	50,000
Accrued long-term co-promotional expenses	53,100
AstraZeneca Agreements [Member] | U.S./RoW [Member]
Schedule of Available-for-sale Securities [Line Items]
Unbilled contract assets	$ 50,000

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