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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Deficit [Member]
Noncontrolling Interests [Member]
Balance at Dec. 31, 2016 $ 135,069 $ 637 $ 625,903 $ (960) $ (509,782) $ 19,271
Balance, Shares at Dec. 31, 2016   63,665,284        
Net loss (120,875) $ 0 0 0 (120,875) 0
Change in unrealized gain or loss on investments 1,187 0 0 1,187 0 0
Foreign currency translation adjustments (2,022) 0 0 (2,022) 0 0
Follow-on Offerings, net of underwriting discounts, commission and issuance costs 470,226 $ 144 470,082 0 0 0
Follow-on Offerings, net of underwriting discounts, commission and issuance costs, Shares   14,428,750        
Shares issued from stock plans, net of payroll taxes paid 26,614 $ 44 26,570 0 0 0
Shares issued from stock plans, net of payroll taxes paid, Shares   4,404,094        
Stock-based compensation 37,539 $ 0 37,539 0 0 0
Balance at Dec. 31, 2017 547,738 $ 825 1,160,094 (1,795) (630,657) 19,271
Balance, Shares at Dec. 31, 2017   82,498,128        
Impact of change in accounting principle upon adoption | ASU 2016-01 [Member] 0 $ 0 0 (1,250) 1,250 0
Net loss (86,420) 0 0 0 (86,420) 0
Change in unrealized gain or loss on investments (7) 0 0 (7) 0 0
Foreign currency translation adjustments 771 0 0 771 0 0
Adjustment to issuance costs for Follow-on Offerings 11 0 11 0 0 0
Shares issued from stock plans, net of payroll taxes paid 14,235 $ 29 14,206 0 0 0
Shares issued from stock plans, net of payroll taxes paid, Shares   2,933,974        
Stock-based compensation 52,142 $ 0 52,142 0 0 0
Balance at Dec. 31, 2018 528,470 $ 854 1,226,453 (2,281) (715,827) 19,271
Balance, Shares at Dec. 31, 2018   85,432,102        
Impact of change in accounting principle upon adoption | ASU 2016-02 [Member] 8,688 $ 0 0 0 8,688 0
Impact of change in accounting principle upon adoption | ASU 2018-02 [Member] 0 0 0 611 (611) 0
Net loss (76,970) 0 0 0 (76,970) 0
Change in unrealized gain or loss on investments 592 0 0 592 0 0
Foreign currency translation adjustments 331 0 0 331 0 0
Shares issued from stock plans, net of payroll taxes paid 7,962 $ 23 7,939 0 0 0
Shares issued from stock plans, net of payroll taxes paid, Shares   2,220,957        
Warrants exercised 66 $ 0 66 0 0 0
Warrants exercised, Shares   4,430        
Stock-based compensation 66,267 $ 0 66,267 0 0 0
Balance at Dec. 31, 2019 $ 535,406 $ 877 $ 1,300,725 $ (747) $ (784,720) $ 19,271
Balance, Shares at Dec. 31, 2019   87,657,489