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Related Party Transactions - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Related Party Transaction [Line Items]
Accounts receivable from related party	$ 4,845,000	$ 47,210,000
Accrued liabilities to related party	36,883,000	444,000
Unbilled contract asset	180,000,000	0
Due from Related Parties, Current	125,210,000	0
Net unbilled contract asset	125,210,000	0
Deferred revenue	54,790,000	0
Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0
Astellas Agreement [Member] | Japan [Member]
Related Party Transaction [Line Items]
Deferred revenue	375,000
Astellas Agreement [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0
Deferred revenue	4,790,000
Astellas [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0
Net unbilled contract asset	125,200,000
Deferred revenue	4,800,000
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	122,500,000	100,000,000.0	$ 20,100,000
Expense related to collaboration agreements	2,800,000	1,500,000	$ 1,000,000.0
Accounts receivable from related party	4,800,000	47,200,000
Accrued liabilities to related party	36,900,000	400,000
Astellas [Member] | Astellas Agreement [Member] | Japan [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party	36,300
API Shipment [Member] | Astellas [Member] | Astellas Agreement [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party		43,800,000
Product Revenue [Member] | API Shipment [Member] | Astellas [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	$ (36,300,000)	$ 64,800,000

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