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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Revenue:    
Total revenue $ 24,401 $ 23,863
Operating costs and expenses:    
Cost of goods sold $ 970 $ 0
Cost, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember
Research and development $ 54,902 $ 50,496
Selling, general and administrative 49,603 22,210
Total operating costs and expenses 105,475 72,706
Loss from operations (81,074) (48,843)
Interest and other, net    
Interest expense (633) (770)
Interest income and other, net 3,165 4,177
Total interest and other, net 2,532 3,407
Loss before income taxes (78,542) (45,436)
Benefit from income taxes (194) (25)
Net loss $ (78,348) $ (45,411)
Net loss per share - basic and diluted $ (0.89) $ (0.53)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 88,219 85,704
License Revenue [Member]    
Revenue:    
Total revenue $ 0 $ 0
Development and Other Revenue [Member]    
Revenue:    
Total revenue 19,446 23,863
Product Revenue, Net [Member]    
Revenue:    
Total revenue $ 4,955 $ 0