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Collaboration Agreements and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) - USD ($) $ in Thousands | Sep. 30, 2020 | Dec. 31, 2019
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Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Deferred Revenue | $ 0 | $ 54,790
Astellas Agreement [Member] | Japan [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 101,567 |
Deferred Revenue | 164 |
Total Consideration | 101,731 |
Astellas Agreement [Member] | Japan [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 15,543 |
Deferred Revenue | 164 |
Total Consideration | 15,707 |
Astellas Agreement [Member] | Japan [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 86,024 |
Deferred Revenue | 0 |
Total Consideration | 86,024 |
Astellas Agreement [Member] | Europe [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 732,785 |
Deferred Revenue | 2,096 |
Total Consideration | 734,881 |
Astellas Agreement [Member] | Europe [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 244,834 |
Deferred Revenue | 2,096 |
Total Consideration | 246,930 |
Astellas Agreement [Member] | Europe [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 487,951 |
Deferred Revenue | 0 |
Total Consideration | 487,951 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 880,026 |
Deferred Revenue | 143,606 |
Total Consideration | 1,023,632 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 341,844 |
Deferred Revenue | 0 |
Total Consideration | 341,844 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | Co-development, information sharing & committee services [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 536,792 |
Deferred Revenue | 2,435 |
Total Consideration | 539,227 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | China performance obligation [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 1,390 |
Deferred Revenue | 141,171 |
Total Consideration | $ 142,561 |

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