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Collaboration Agreements and Revenues (Tables) | 12 Months Ended
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Dec. 31, 2020
Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue and Product Revenue Net | Product revenue, net was as follows (in thousands):
|  | Years Ended December 31, |
|  | 2020 |  |  | 2019 |
Gross revenue |  | $ | 89,027 |  |  | $ | 2,803 |
Price adjustment |  |  | — |  |  |  | (936 | )
Non-key account hospital listing award |  |  | (9,325 | ) |  |  | — |
Contractual sales rebate |  |  | (6,189 | ) |  |  | (149 | )
Other discounts and rebates |  |  | (923 | ) |  |  | (18 | )
Sales return |  |  | (92 | ) |  |  | — |
Product revenue, net |  | $ | 72,498 |  |  | $ | 1,700 |
Roll-forward of Related Contract Liabilities | . The following table includes a roll-forward of the related contract liabilities (in thousands):
|  | Balance at December 31, 2019 |  |  | Additions |  |  | Deduction |  |  | Currency Translation and Other |  |  | Gross Contract Liabilities Balance |  |  | Balance Presented Net Against Accounts Receivable |  |  | Balance at December 31, 2020 |
Product revenue - Contract liabilities |  | $ | (1,102 | ) |  | $ | (16,497 | ) |  | $ | 2,184 |  |  | $ | (270 | ) |  | $ | (15,685 | ) |  | $ | 548 |  |  | $ | (15,137 | )
Schedule of Drug Product Revenue | Drug product revenue was as follows (in thousands):
|  | Years Ended December 31, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Astellas |  | $ | 4,281 |  |  | $ | (36,324 | ) |  | $ | 64,776 |
AstraZeneca |  |  | 4,625 |  |  |  | — |  |  |  | — |
Drug product revenue |  | $ | 8,906 |  |  | $ | (36,324 | ) |  | $ | 64,776 |
Drug Product Revenue [Member] |
Roll-forward of Related Contract Liabilities | The following table includes a roll-forward of the related contract liabilities (in thousands):
|  | Balance at December 31, 2019 |  |  | Additions |  |  | Balance at December 31, 2020 |
Drug product revenue - Astellas - contract liabilities |  | $ | — |  |  | $ | (5,984 | ) |  | $ | (5,984 | )
Japan [Member] |
Summary of License Revenue and Development Revenue Recognized under Agreement | Amounts recognized as license revenue and development revenue under the Japan Agreement with Astellas were as follows (in thousands):
|  |  |  | Years Ended December 31, |
Agreement |  | Performance Obligation |  | 2020 |  |  | 2019 |  |  | 2018 |
Japan |  | License revenue |  | $ | 14,323 |  |  | $ | 11,935 |  |  | $ | 14,323 |
|  | Development revenue |  | $ | 1,220 |  |  | $ | 1,222 |  |  | $ | 2,400 |
Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue and Product Revenue Net | The transaction price related to consideration received and accounts receivable has been allocated to each of the following performance obligations under the Japan Agreement, along with any associated deferred revenue as follows (in thousands):
Japan Agreement |  | Cumulative Revenue Through December 31, 2020 |  |  | Deferred Revenue at December 31, 2020 |  |  | Total Consideration Through December 31, 2020 |
License |  | $ | 100,347 |  |  | $ | — |  |  | $ | 100,347 |
Development revenue |  |  | 16,350 |  |  |  | 130 |  |  |  | 16,480 |
Total license and development revenue |  | $ | 116,697 |  |  | $ | 130 |  |  | $ | 116,827 |
Europe [Member] |
Summary of License Revenue and Development Revenue Recognized under Agreement | Amounts recognized as license revenue and development revenue under the Europe Agreement with Astellas were as follows (in thousands):
|  |  |  | Years Ended December 31, |
Agreement |  | Performance Obligation |  | 2020 |  |  | 2019 |  |  | 2018 |
Europe |  | License revenue |  | $ | — |  |  | $ | 117,470 |  |  | $ | — |
|  | Development revenue |  | $ | 17,954 |  |  | $ | 28,172 |  |  | $ | 18,503 |
Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue and Product Revenue Net | The transaction price related to consideration received and accounts receivable has been allocated to each of the following performance obligations under the Europe Agreement with Astellas, along with any associated deferred revenue as follows (in thousands):
Europe Agreement |  | Cumulative Revenue Through December 31, 2020 |  |  | Deferred Revenue at December 31, 2020 |  |  | Total Consideration Through December 31, 2020 |
License |  | $ | 487,951 |  |  | $ | — |  |  | $ | 487,951 |
Development revenue |  |  | 248,962 |  |  |  | 1,429 |  |  |  | 250,391 |
Total license and development revenue |  | $ | 736,913 |  |  | $ | 1,429 |  |  | $ | 738,342 |
U.S./RoW and China [Member] |
Summary of License Revenue and Development Revenue Recognized under Agreement | Amounts recognized as license revenue and development revenue under the U.S./RoW and China Agreements with AstraZeneca were as follows (in thousands):
|  |  |  | Years Ended December 31, |
Agreement |  | Performance Obligation |  | 2020 |  |  | 2019 |  |  | 2018 |
U.S. / RoW and China |  | License revenue |  | $ | — |  |  | $ | 47,681 |  |  | $ | 7,946 |
|  | Development revenue |  |  | 61,508 |  |  |  | 84,629 |  |  |  | 104,970 |
|  | China performance obligation |  | $ | (90 | ) |  | $ | 90 |  |  | $ | — |
Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue and Product Revenue Net | The transaction price related to consideration received and accounts receivable has been allocated to each of the following performance obligations under the U.S./RoW Agreement and China Agreement, along with any associated deferred revenue as follows (in thousands):
U.S. / RoW and China Agreements |  | Cumulative Revenue Through December 31, 2020 |  |  | Deferred Revenue at December 31, 2020 |  |  | Total Consideration Through December 31, 2020 |
License |  | $ | 341,844 |  |  | $ | — |  |  | $ | 341,844 |
Co-development, information sharing & committee services |  |  | 554,775 |  |  |  | 2,276 |  |  |  | 557,051 |
China performance obligation |  |  | — |  |  |  | 137,338 |  |  |  | 137,338 |
Total license and development revenue |  | $ | 896,619 |  |  | $ | 139,614 |  | * | $ | 1,036,233 |
* | Contract assets and liabilities related to rights and obligations in the same contract are recorded net on the consolidated balance sheets. As of December 31, 2020, deferred revenue included $137.5 million related to the U.S./RoW and China Agreement, which represents the net of $139.6 million of deferred revenue presented above and a $2.1 million unbilled co-development revenue under the China Amendment with AstraZeneca.

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