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Collaboration Agreements and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 176,319 | $ 256,577 | $ 212,958
License Revenue [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 14,323 | 177,086 | 22,269
Development Revenue [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 80,592 | 114,115 | 125,913
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 14,323 | 11,935 | 14,323
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 117,470 | 0
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 1,220 | 1,222 | 2,400
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 17,954 | 28,172 | 18,503
AstraZeneca Agreements [Member] | China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | (90) | 90 | 0
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 47,681 | 7,946
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 61,508 | $ 84,629 | $ 104,970

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