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Equity and Stock-based Compensation - Schedule of Recorded Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total stock-based compensation expense | $ 72,720 | $ 66,267 | $ 52,142
Research and development [Member] |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total stock-based compensation expense | 46,229 | 41,015 | 30,491
Selling, General and Administrative Expenses [Member] |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total stock-based compensation expense | $ 26,491 | $ 25,252 | $ 21,651

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