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Collaboration Agreements and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2020 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | $ 176,319,000 | $ 256,577,000 | $ 212,958,000
Deferred revenue ($2,907 and $249 to a related party) |  | 6,547,000 | 490,000 |
Deferred revenue |  | 138,474,000 | 99,449,000 |
U.S./RoW [Member] | AstraZeneca Agreements [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | 4,600 |  |
Deferred revenue |  | 137,500,000 |  |
Drug Product Revenue [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | 8,906,000 | (36,324,000) | 64,776,000
Estimated variable consideration transaction price |  |  | 36,300,000 |
Drug Product Revenue [Member] | AstraZeneca Agreements [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | 4,625,000 | 0 | 0
Drug Product Revenue [Member] | API Shipment [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | 4,000,000.0 |  |
Drug Product Revenue [Member] | Japan [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | $ 8,200,000 |  |  | 64,800,000
Drug Product Revenue [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  | 4,300,000 | $ (36,300,000) | $ 64,800,000
Drug Product Revenue [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Deferred revenue ($2,907 and $249 to a related party) |  | 1,400,000 |  |
Deferred revenue |  | $ 4,600,000 |  |

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