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Collaboration Agreements and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Deferred Revenue | $ 2,147 | $ 54,790
Astellas Agreement [Member] | Japan [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 116,697 |
Deferred Revenue | 130 |
Total Consideration | 116,827 |
Astellas Agreement [Member] | Japan [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 100,347 |
Deferred Revenue | 0 |
Total Consideration | 100,347 |
Astellas Agreement [Member] | Japan [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 16,350 |
Deferred Revenue | 130 |
Total Consideration | 16,480 |
Astellas Agreement [Member] | Europe [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 736,913 |
Deferred Revenue | 1,429 |
Total Consideration | 738,342 |
Astellas Agreement [Member] | Europe [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 487,951 |
Deferred Revenue | 0 |
Total Consideration | 487,951 |
Astellas Agreement [Member] | Europe [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 248,962 |
Deferred Revenue | 1,429 |
Total Consideration | 250,391 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 896,619 |
Deferred Revenue | 139,614 |
Total Consideration | 1,036,233 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 341,844 |
Deferred Revenue | 0 |
Total Consideration | 341,844 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | Co-development, information sharing & committee services [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 554,775 |
Deferred Revenue | 2,276 |
Total Consideration | 557,051 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | China performance obligation [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 0 |
Deferred Revenue | 137,338 |
Total Consideration | $ 137,338 |

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