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Collaboration Agreements and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) |  |  |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Dec. 29, 2018 | Dec. 17, 2018 | Jul. 30, 2013 | Dec. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2015 | Jun. 30, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Unbilled contract asset |  |  |  | $ 2,147,000 | $ 2,147,000 | $ 180,000,000 |  |  |
Drug product revenue |  |  |  |  | 176,319,000 | 256,577,000 | $ 212,958,000 |  |
Accrued long-term co-promotion expenses |  |  |  | 27,424,000 | 27,424,000 | 53,071,000 |  |  |
Accrued long term co promotion liability current |  |  |  | 11,500,000 | 11,500,000 |  |  |  |
Deferred revenue ($2,907 and $249 to a related party) |  |  |  | 6,547,000 | 6,547,000 | 490,000 |  |  |
Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Drug product revenue |  |  |  |  | 8,906,000 | (36,324,000) | 64,776,000 |  |
AstraZeneca Agreements [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Transaction price and allocated to performance obligations |  |  |  |  |  |  |  |  | $ 50,000,000.0
Revenue during period from performance obligations |  |  |  | 600,000 | $ 600,000 | 42,400,000 |  |  |
Unbilled contract asset |  |  |  |  |  | 50,000,000.0 |  |  |
Estimated joint development extended service period |  |  |  |  | 2024 |  |  |  |
Historical co-promotion costs |  |  |  |  | $ 0 |  |  |  |
AstraZeneca Agreements [Member] | Selling, General and Administrative Expenses [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Reversal of accrued co-promotion expenses |  |  |  | 84,400,000 |  |  |  |  |
Co-promotion expenses |  |  |  |  | 27,200,000 |  |  |  |
AstraZeneca Agreements [Member] | Other Noncurrent Liabilities |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Accrued long-term co-promotion expenses |  |  |  | 27,400,000 | 27,400,000 |  |  |  |
AstraZeneca Agreements [Member] | Accounts Payable [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Accrued long term co promotion liability current |  |  |  | 16,900,000 | 16,900,000 |  |  |  |
AstraZeneca Agreements [Member] | Accrued Liabilities [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Accrued long term co promotion liability current |  |  |  | 11,500 | 11,500 |  |  |  |
AstraZeneca Agreements [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Drug product revenue |  |  |  |  | 4,625,000 | 0 | 0 |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments |  |  | $ 374,000,000.0 |  |  |  |  |  |
Potential milestone payments |  |  | 875,000,000.0 |  |  |  |  |  |
Commercial sales milestone |  |  | 325,000,000.0 |  |  |  |  |  |
Aggregate considerations received excluding drug product revenue |  |  |  | 439,000,000.0 | $ 439,000,000.0 |  |  |  |
Shared development costs |  |  |  |  |  |  |  | $ 233,000,000.0 |
Additional consideration based on net sales description |  |  |  |  | low 20% range |  |  |  |
Unbilled contract asset |  |  |  |  |  | 50,000,000.0 |  |  |
Drug product revenue |  |  |  |  | $ 4,600 |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | FibroGen, Inc. [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Shared development costs |  |  |  |  |  |  |  | $ 116,500,000 |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 65,000,000.0 |  |  |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 325,000,000.0 |  |  |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Deferred Approval Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 160,000,000.0 |  |  |  |  |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 348,500,000 |  | 22,000,000.0 |  |  |  |
Drug product revenue |  |  |  |  | (90,000) | 90,000 | 0 |  |
Proceeds from upfront, non-contingent and non-refundable payments |  |  | 28,200,000 |  |  |  |  |  |
Commercial sales and other events milestone |  |  | 187,500,000 |  |  |  |  |  |
Aggregate considerations received |  |  |  | 77,200,000 | 77,200,000 |  |  |  |
Milestone payment received |  |  |  |  |  | $ 18,700,000 |  |  |
Milestone payment, revenue recognition | $ 6,000,000.0 | $ 6,000,000.0 |  |  | 12,000,000.0 |  | $ 9,900,000 |  |
Deferred revenue ($2,907 and $249 to a related party) |  |  |  | 7,000,000.0 | 7,000,000.0 |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Accrued and Other Current Liabilities [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Deferred revenue ($2,907 and $249 to a related party) |  |  |  | $ 7,000,000.0 | $ 7,000,000.0 |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 15,000,000.0 |  |  |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 146,000,000.0 |  |  |  |  |  |

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