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Summary of Significant Accounting Policies - Additional Information (Detail)
 12 Months Ended
Dec. 31, 2020
USD ($)
Segment
Apr. 01, 2020
USD ($)
Dec. 31, 2019
USD ($)
Jan. 01, 2019
USD ($)
Jan. 01, 2018
USD ($)
Accounting Policy [Line Items]          
Number of operating segment | Segment 1        
Currency translation adjustment   $ 1,300,000      
Highly liquid investment maturity period three months or less        
Restricted time deposits $ 2,072,000   $ 2,072,000    
Cash and cash equivalents $ 678,393,000   126,266,000    
Short term investments maturity 12 months        
Long term Investments Maturity 12 months        
Impairment of long-lived assets $ 0        
Description of payment term The period between the transfer of control of the promised goods and when the Company receives payment is based on a general 60-day payment term.        
Description of sales return Distributors can request to return product to the Company only due to quality issues or for product purchased within one year prior to the product’s expiration date        
Accumulated deficit $ (974,011,000)   (784,720,000)    
Accumulated other comprehensive loss (4,499,000)   (747,000)    
ASU 2018-02 [Member] | Impact of change in accounting principle upon adoption of ASU 2018-02 [Member]          
Accounting Policy [Line Items]          
Accumulated deficit       $ 600,000  
Accumulated other comprehensive loss       (600,000)  
ASU 2016-01 [Member] | Impact of change in accounting principle upon adoption of ASU 2016-01 [Member]          
Accounting Policy [Line Items]          
Accumulated deficit         $ (1,300,000)
Accumulated other comprehensive loss         $ 1,300,000
Cumulative Effect, Period of Adoption, Adjustment [Member] | ASU 2016-02 [Member]          
Accounting Policy [Line Items]          
Accumulated deficit       $ (8,700,000)  
Europe [Member] | Astellas Agreement [Member]          
Accounting Policy [Line Items]          
Amount constrained related to drug product shipment $ 6,000,000.0        
Minimum [Member] | Computer Equipment [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 3 years        
Minimum [Member] | Laboratory Equipment [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 3 years        
Minimum [Member] | Machinery [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 3 years        
Minimum [Member] | Furniture and Fixtures [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 3 years        
Maximum [Member] | Computer Equipment [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 5 years        
Maximum [Member] | Laboratory Equipment [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 5 years        
Maximum [Member] | Machinery [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 5 years        
Maximum [Member] | Furniture and Fixtures [Member]          
Accounting Policy [Line Items]          
Property and equipment estimated useful life 5 years        
Foreign subsidiaries [Member]          
Accounting Policy [Line Items]          
Cash and cash equivalents $ 66,000,000.0   $ 11,900,000    
Accounts Receivable from Distributors [Member] | Credit Concentration Risk [Member]          
Accounting Policy [Line Items]          
Concentration risk, percentage 64.00%