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Related Party Transactions - Additional Information (Detail) - USD ($)	1 Months Ended	12 Months Ended
	Sep. 30, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Jun. 30, 2020
Related Party Transaction [Line Items]
Accounts receivable from related party		$ 4,127,000	$ 4,845,000
Deferred revenue		2,147,000	54,790,000
Unbilled contract asset		2,147,000	180,000,000
Net unbilled contract asset		0	125,210,000
Accrued liabilities and accounts payable to related party		24,000	36,883,000
Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset					$ 130,000,000.0
Astellas [Member]
Related Party Transaction [Line Items]
Drug product revenue from a related party		4,300,000	(36,300,000)	$ 64,800,000
Accrued liabilities and accounts payable to related party		1,100,000	36,900,000
Astellas [Member] | Japan [Member]
Related Party Transaction [Line Items]
Drug product revenue from a related party		8,200,000
Astellas [Member] | Europe [Member]
Related Party Transaction [Line Items]
Deferred revenue			4,800,000
Unbilled contract asset			130,000,000.0
Net unbilled contract asset		0	125,200,000
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Expense related to collaboration agreements		500,000	2,800,000	1,500,000
Accounts receivable from related party		4,100,000	4,800,000
Deferred revenue		7,500,000	400,000
Falikang [Member]
Related Party Transaction [Line Items]
Investment	$ 2,800,000
Percentage of outstanding shares owned	51.10%
Equity method investments		2,700,000
Miscellaneous receivables		900,000
API Shipment [Member]
Related Party Transaction [Line Items]
License and development revenue related to collaboration agreements			36,300,000
API Shipment [Member] | Astellas [Member] | Japan [Member]
Related Party Transaction [Line Items]
License and development revenue related to collaboration agreements		(4,000,000.0)	(36,300,000)	64,800,000
License and Development [Member] | Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
License and development revenue related to collaboration agreements		33,500,000	158,800,000	$ 35,200,000
Product [Member]
Related Party Transaction [Line Items]
Deferred revenue		$ 15,137,000	$ 1,102,000

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