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Collaboration Agreements and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 3 Months Ended
--- | --- | ---
Jul. 30, 2013 | Mar. 31, 2021 | Mar. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | $ 38,429 | $ 24,401
Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | 15,362 | 4,955
Drug Product Revenue [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | 8,480 |
AstraZeneca Agreements [Member] | Drug Product Revenue [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | 4,450 |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 374,000 |  |
Potential milestone payments | 875,000 |  |
Commercial sales milestone | 325,000 |  |
Aggregate consideration received excluding drug product revenue |  | 439,000 |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Clinical and Development Milestone [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | 65,000 |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Regulatory Milestone [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | 325,000 |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Deferred Approval Milestone [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | 160,000 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | 348,500 |  |
Drug product revenue |  | 0 | 153
Proceeds from upfront, non-contingent and non-refundable payments | 28,200 |  |
Commercial sales and other events milestone | 187,500 |  |
Aggregate consideration received for milestone and upfront payments |  | 77,200 |
AstraZeneca Agreements [Member] | China [Member] | Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | 10,400 |
AstraZeneca Agreements [Member] | China [Member] | Clinical and Development Milestone [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | 15,000 |  |
AstraZeneca Agreements [Member] | China [Member] | Regulatory Milestone [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential milestone payments | $ 146,000 |  |
Direct Sales [Member] | Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | 4,956 | $ 4,955
Direct Sales [Member] | China [Member] | Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue |  | $ 5,000 |

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