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Balance Sheet Components (Tables)

3 Months Ended

Mar. 31, 2021

Organization Consolidation And Presentation Of Financial Statements [Abstract]

Schedule of Cash and Cash Equivalents

Cash and cash equivalents consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Cash		$	100,735			$	88,046
Commercial paper			41,419				—
Corporate bonds			9,085				—
Money market funds			282,269				590,347
Total cash and cash equivalents		$	433,508			$	678,393

Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments

The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):

		March 31, 2021
		Amortized Cost				Gross Unrealized Holding Gains				Gross Unrealized Holding Losses				Fair Value
Corporate bonds		$	75,503			$	4			$	(54	)		$	75,453
Commercial paper			59,536				4				(1	)			59,539
U.S. government bonds			30,060				2				(3	)			30,059
Agency bonds			14,349				1				(3	)			14,347
Asset-backed securities			12,573				—				(4	)			12,569
Foreign government bonds			12,195				1				(2	)			12,194
Equity investments			125				117				—				242
Total investments		$	204,341			$	129			$	(67	)		$	204,403
		December 31, 2020
		Amortized Cost				Gross Unrealized Holding Gains				Gross Unrealized Holding Losses				Fair Value
Bond and mutual funds		$	8,147			$	—			$	(3	)		$	8,144
Equity investments			125				119				—				244
Total investments		$	8,272			$	119			$	(3	)		$	8,388

Schedule of Inventory

Inventories consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Raw materials		$	3,308			$	2,303
Work-in-progress			9,661				8,114
Finished goods			7,795				6,113
Total inventories		$	20,764			$	16,530

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Unbilled contract assets		$	7,721			$	2,147
Deferred revenues from associated contracts			(3,691	)			(2,147	)
Net unbilled contract assets			4,030				—
Prepaid assets			9,602				8,353
Other current assets			2,523				1,807
Total prepaid expenses and other current assets		$	16,155			$	10,160

Schedule of Property and Equipment

Property and equipment consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Leasehold improvements		$	102,265			$	102,006
Laboratory equipment			18,541				18,143
Machinery			8,231				8,312
Computer equipment			9,107				9,545
Furniture and fixtures			6,195				6,128
Construction in progress			228				760
Total property and equipment		$	144,567			$	144,894
Less: accumulated depreciation			(113,634	)			(111,247	)
Property and equipment, net		$	30,933			$	33,647

Schedule of Accrued and Other Current Liabilities

Accrued and other current liabilities consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Preclinical and clinical trial accruals		$	39,775			$	44,113
Payroll and related accruals			15,473				22,800
Contract liabilities to pharmaceutical distributors			15,979				15,137
Accrued co-promotion expenses - current			17,431				11,537
Roxadustat profit share to AstraZeneca			7,007				7,007
Property taxes and other taxes			9,242				5,970
Professional services			5,948				4,869
Other			8,926				8,088
Total accrued and other current liabilities		$	119,781			$	119,521

Schedule of Other Long-term Liabilities

Other long-term liabilities consisted of the following (in thousands):

		March 31, 2021				December 31, 2020
Accrued long-term co-promotion expenses		$	23,295			$	27,424
Other long-term tax liabilities			9,025				8,675
Operating lease liabilities, non-current			3,354				853
Other			2,661				2,690
Total other long-term liabilities		$	38,335			$	39,642

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