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Collaboration Agreements and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	$ 38,429	$ 24,401
License Revenue [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0
Development Revenue [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	14,587	19,446
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	80	163
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	3,531	4,574
AstraZeneca Agreements [Member] | China [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	153
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	$ 10,976	$ 14,556

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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