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Balance Sheet Components (Tables)

6 Months Ended

Jun. 30, 2021

Organization Consolidation And Presentation Of Financial Statements [Abstract]

Cash and cash equivalents consisted of the following (in thousands):

	June 30, 2021		December 31, 2020
Cash	$	130,035	$	88,046
Commercial paper		2,699		—
Money market funds		220,627		590,347
Total cash and cash equivalents	$	353,361	$	678,393

Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments

The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):

	June 30, 2021
	Amortized Cost		Gross Unrealized Holding Gains		Gross Unrealized Holding Losses			Fair Value
Corporate bonds	$	104,499	$	27	$	(43	)	$	104,483
Commercial paper		69,400		—		—			69,400
U.S. government bonds		46,589		—		(21	)		46,568
Agency bonds		14,288		2		(6	)		14,284
Asset-backed securities		12,489		1		—			12,490
Foreign government bonds		12,151		1		(1	)		12,151
Equity investments		118		115		—			233
Total investments	$	259,534	$	146	$	(71	)	$	259,609

	December 31, 2020
	Amortized Cost		Gross Unrealized Holding Gains		Gross Unrealized Holding Losses			Fair Value
Bond and mutual funds	$	8,147	$	—	$	(3	)	$	8,144
Equity investments		125		119		—			244
Total investments	$	8,272	$	119	$	(3	)	$	8,388

Schedule of Inventory

Inventories consisted of the following (in thousands):

	June 30, 2021		December 31, 2020
Raw materials	$	1,190	$	2,303
Work-in-progress		15,541		8,114
Finished goods		7,799		6,113
Total inventories	$	24,530	$	16,530

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):

	June 30, 2021			December 31, 2020
Unbilled contract assets	$	5,256		$	2,147
Deferred revenues from associated contracts		(5,256	)		(2,147	)
Net unbilled contract assets		—			—
Prepaid assets		7,149			8,353
Other current assets		1,309			1,807
Total prepaid expenses and other current assets	$	8,458		$	10,160

Schedule of Property and Equipment

Property and equipment consisted of the following (in thousands):

	June 30, 2021			December 31, 2020
Leasehold improvements	$	102,657		$	102,006
Laboratory equipment		19,247			18,143
Machinery		8,387			8,312
Computer equipment		9,205			9,545
Furniture and fixtures		6,126			6,128
Construction in progress		1,407			760
Total property and equipment	$	147,029		$	144,894
Less: accumulated depreciation		(116,359	)		(111,247	)
Property and equipment, net	$	30,670		$	33,647

Schedule of Accrued and Other Current Liabilities

Accrued and other current liabilities consisted of the following (in thousands):

	June 30, 2021		December 31, 2020
Preclinical and clinical trial accruals	$	65,274	$	44,113
Payroll and related accruals		18,047		22,800
Contract liabilities to pharmaceutical distributors		13,793		15,137
Accrued co-promotion expenses - current		20,832		11,537
Roxadustat profit share to AstraZeneca		7,007		7,007
Property taxes and other taxes		10,344		5,970
Professional services		7,471		4,869
Other		5,033		6,900
Total accrued and other current liabilities	$	147,801	$	118,333

Schedule of Other Long-term Liabilities

Other long-term liabilities consisted of the following (in thousands):

	June 30, 2021		December 31, 2020
Accrued long-term co-promotion expenses	$	19,205	$	27,424
Other long-term tax liabilities		8,985		8,675
Other		2,469		2,690
Total other long-term liabilities	$	30,659	$	38,789