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Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020
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Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Deferred Revenue | $ 7,003 | $ 2,147
Astellas Agreement [Member] | Japan [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 116,942 |
Deferred Revenue | 0 |
Total Consideration | 116,942 |
Astellas Agreement [Member] | Japan [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 16,595 |
Deferred Revenue | 0 |
Total Consideration | 16,595 |
Astellas Agreement [Member] | Japan [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 100,347 |
Deferred Revenue | 0 |
Total Consideration | 100,347 |
Astellas Agreement [Member] | Europe [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 865,485 |
Deferred Revenue | 0 |
Total Consideration | 865,485 |
Astellas Agreement [Member] | Europe [Member] | Development Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 269,100 |
Deferred Revenue | 0 |
Total Consideration | 269,100 |
Astellas Agreement [Member] | Europe [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 596,385 |
Deferred Revenue | 0 |
Total Consideration | 596,385 |
AstraZeneca Agreements [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Deferred Revenue | 160,267 | $ 137,338
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 969,052 |
Deferred Revenue | 161,695 |
Total Consideration | 1,130,747 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | License Revenue [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 341,844 |
Deferred Revenue | 0 |
Total Consideration | 341,844 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | Co-development, information sharing & committee services [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 594,713 |
Deferred Revenue | 1,428 |
Total Consideration | 596,141 |
AstraZeneca Agreements [Member] | U.S./RoW and China [Member] | China performance obligation [Member] |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 32,495 |
Deferred Revenue | 160,267 |
Total Consideration | $ 192,762 |

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