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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | ---
Jul. 30, 2013 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred Revenue |  | $ 23,256 |  | $ 23,256 |  | $ 6,547
Revenue recognized |  | 155,973 | $ 44,032 | 218,766 | $ 111,320 |
Product Revenue, Net [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized |  | 13,442 | 22,683 | 42,175 | 43,331 |
Drug Product Revenue [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred Revenue |  | 11,200 |  | 11,200 |  |
Revenue recognized |  | 0 | 686 | (168) | 8,924 |
AstraZeneca Agreements [Member] | Drug Product Revenue [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred Revenue |  | 11,200 |  | 11,200 |  |
Revenue recognized |  | 0 | 4,643 | (2,224) | 4,643 |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 374,000 |  |  |  |  |
Potential milestone payments | 875,000 |  |  |  |  |
Commercial sales milestone | 325,000 |  |  |  |  |
Aggregate consideration received excluding drug product revenue |  | 439,000 |  | 439,000 |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | 65,000 |  |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Regulatory Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | 325,000 |  |  |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] | Deferred Approval Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | 160,000 |  |  |  |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | 348,500 |  |  |  |  |
Deferred Revenue |  | 7,800 |  | 7,800 |  | $ 7,000
Proceeds from upfront, non-contingent and non-refundable payments | 28,200 |  |  |  |  |
Commercial sales and other events milestone | 187,500 |  |  |  |  |
Aggregate consideration received for milestone and upfront payments |  | 77,200 |  | 77,200 |  |
Revenue recognized |  | 0 | 706 | 0 | 1,300 |
AstraZeneca Agreements [Member] | China [Member] | Product Revenue, Net [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized |  | 10,300 |  | 32,500 |  |
AstraZeneca Agreements [Member] | China [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | 15,000 |  |  |  |  |
AstraZeneca Agreements [Member] | China [Member] | Regulatory Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments | $ 146,000 |  |  |  |  |
Direct Sales [Member] | Product Revenue, Net [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized |  | 3,114 | $ 22,683 | 9,680 | $ 43,331 |
Direct Sales [Member] | China [Member] | Product Revenue, Net [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized |  | $ 3,100 |  | $ 9,700 |  |

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