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v3.21.2

Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Operating activities |  |
Net loss | $ (155,945) | $ (130,657)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation | 7,717 | 8,671
Amortization of finance lease right-of-use assets | 4,509 | 7,886
Net accretion of premium and discount on investments | 1,447 | 103
Unrealized loss on equity investments | 12 | (3)
Investment (gain) loss in unconsolidated variable interest entity | (664) | 13
Loss (gain) on disposal of property and equipment | 232 | (3)
Stock-based compensation | 54,089 | 52,451
Expense for acquired in-process research and development asset | 25,000 | 0
Realized loss on sales of available-for-sale securities | 8 | 258
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 6,131 | 2,520
Inventories | (12,658) | (5,206)
Prepaid expenses and other current assets | (11,160) | 121,923
Operating lease right-of-use assets | 1,232 | 678
Other assets | (3,563) | 6,857
Accounts payable | (1,115) | 1,440
Accrued and other liabilities | 31,997 | 3,478
Operating lease liabilities, current | 410 | (229)
Deferred revenue | 40,650 | 45,925
Accrued interest for finance lease liabilities | (76) | (196)
Operating lease liabilities, non-current | (1,326) | (479)
Other long-term liabilities | (14,199) | (26,600)
Net cash provided by (used in) operating activities | (27,272) | 88,830
Investing activities |  |
Purchases of property and equipment | (3,790) | (1,604)
Payment made for acquired in-process research and development asset | (25,000) | 0
Payment made for investment in unconsolidated variable interest entity | 0 | (2,145)
Purchases of available-for-sale securities | (397,909) | (38)
Proceeds from sales of available-for-sale securities | 4,000 | 10,606
Proceeds from maturities of investments | 46,294 | 301,900
Net cash provided by (used in) investing activities | (376,405) | 308,719
Financing activities |  |
Repayments of finance lease liabilities | (5,359) | (9,254)
Repayments of lease obligations | (302) | (302)
Cash paid for payroll taxes on restricted stock unit releases | (6,734) | (9,007)
Proceeds from issuance of common stock | 11,863 | 26,247
Net cash provided by (used in) financing activities | (532) | 7,684
Effect of exchange rate change on cash and cash equivalents | 343 | 969
Net increase (decrease) in cash and cash equivalents | (403,866) | 406,202
Total cash and cash equivalents at beginning of period | 678,393 | 126,266
Total cash and cash equivalents at end of period | $ 274,527 | $ 532,468

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