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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 35 Months Ended | 45 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Apr. 30, 2006 | Jun. 30, 2005 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Feb. 28, 2009 | Feb. 28, 2009 | Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  |  | $ 155,973 | $ 44,032 | $ 218,766 | $ 111,320 |  |  |
Deferred Revenue |  |  | 23,256 |  | 23,256 |  |  |  | $ 6,547
Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  |  | 0 | $ 686 | (168) | $ 8,924 |  |  |
Deferred Revenue |  |  | 11,200 |  | $ 11,200 |  |  |  |
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  | $ 40,100 |
Potential milestone payments |  | $ 132,500 |  |  |  |  |  |  |
Commercial sales milestone |  | 15,000 |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  | the low 20% range of the list price |  |  |  |
Aggregate consideration received excluding drug product revenue |  |  | 105,100 |  | $ 105,100 |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  | 22,500 |  |  |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  | $ 95,000 |  |  |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  |  | 2,100 |  | $ 2,100 |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  | $ 320,000 |  |
Potential milestone payments |  |  | 120,000 |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  | low 20% range |  |  |  |
Aggregate consideration received excluding drug product revenue |  |  | 660,000 |  | $ 660,000 |  |  |  |
Development and regulatory approval milestones | $ 425,000 |  |  |  |  |  |  |  |
Percentage of joint development costs committed to fund | 50.00% |  |  |  |  |  |  |  |
Transaction price and allocated to performance obligations |  |  | 120,000 |  | 120,000 |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 90,000 |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 335,000 |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Deferred Revenue |  |  | $ 11,800 |  | $ 11,800 |  |  |  |

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