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Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020
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Accrued Liabilities Current [Abstract] |  |
Preclinical and clinical trial accruals | $ 64,212 | $ 44,113
Payroll and related accruals | 20,121 | 22,800
Contract liabilities to pharmaceutical distributors | 10,335 | 15,137
Accrued co-promotion expenses - current | 27,071 | 11,537
Roxadustat profit share to AstraZeneca | 7,764 | 7,007
Property taxes and other taxes | 11,532 | 5,970
Professional services | 4,565 | 4,869
Other | 5,746 | 6,900
Total accrued and other current liabilities | $ 151,346 | $ 118,333

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- Definition Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to pre-clinical and clinical trial activities, including those performed by third parties. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References No definition available. + Details
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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=124098289&loc=d3e6911-107765 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=124098289&loc=d3e6935-107765 + Details
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