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Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
USD ($)
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 $ (2,147)
Balance at September 30, 2021 (7,003)
AstraZeneca Agreements [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 (137,338)
Additions (55,424)
Recognized as Revenue 32,495
Balance at September 30, 2021 (160,267)
Product Revenue, Net [Member] | Direct Sales [Member] | Contract Liabilities [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 (15,137)
Additions (944)
Deduction 5,913
Currency Translation and Other (167)
Balance at September 30, 2021 (10,335)
Drug Product Revenue [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 (5,984)
Additions (24,904)
Recognized as Revenue 0
Balance at September 30, 2021 (30,888)
Drug Product Revenue [Member] | AstraZeneca Agreements [Member] | U.S. [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 0
Additions (11,171)
Recognized as Revenue 0
Balance at September 30, 2021 (11,171)
Drug Product Revenue [Member] | Astellas Agreement [Member] | Japan [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 0
Additions (1,974)
Recognized as Revenue 0
Balance at September 30, 2021 (1,974)
Drug Product Revenue [Member] | Astellas Agreement [Member] | Europe [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2020 (5,984)
Additions (11,759)
Recognized as Revenue 0
Balance at September 30, 2021 $ (17,743)