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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net loss | $ (290,023) | $ (189,291) | $ (76,970)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation | 10,170 | 11,678 | 11,147
Amortization of finance lease right-of-use assets | 4,639 | 10,369 | 10,307
Net accretion of premium and discount on investments | 2,482 | 103 | (3,667)
Unrealized loss on equity investments | 30 | 0 | (88)
Investment (gain) loss in unconsolidated variable interest entity | (1,007) | 202 | 0
Loss (gain) on disposal of property and equipment | 233 | 933 | (42)
Stock-based compensation | 71,161 | 72,720 | 66,267
Expense for acquired in-process research and development asset | 60,000 | 0 | 0
Realized loss on sales of available-for-sale securities | 0 | 258 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net ($(6,803), $718 and $42,365 from related parties) | 25,180 | (11,973) | 35,229
Inventories | (14,158) | (9,175) | (6,887)
Prepaid expenses and other current assets ($889, $124,321 and $(125,210) from a related party) | (9,854) | 123,492 | (128,598)
Operating lease right-of-use assets | 4,209 | (24) | (1,201)
Other assets | (4,412) | 5,843 | (4,058)
Accounts payable ($(1,118), $1,118 and $0 from a related party) | 805 | 17,731 | (3,051)
Accrued and other liabilities ($(20), $(36,859) and $36,439 from a related party) | 16,380 | 30,914 | 17,707
Operating lease liabilities, current | 503 | 134 | 580
Deferred revenue ($21,549, $7,169 and $(3,137) from related parties) | 57,637 | 45,077 | (49,941)
Accrued interest for finance lease liabilities | (75) | (177) | 194
Operating lease liabilities, non-current | (4,043) | (143) | 692
Other long-term liabilities | (12,089) | (27,069) | 53,675
Net cash provided by (used in) operating activities | (82,232) | 81,602 | (78,705)
Investing activities |  |  |
Purchases of property and equipment | (5,186) | (3,994) | (5,762)
Payment made for acquired in-process research and development asset | (25,000) | 0 | 0
Payment made for investment in unconsolidated variable interest entity | 0 | (3,896) | 0
Proceeds from equity transfer of unconsolidated variable interest entity | 0 | 1,063 | 0
Proceeds from sale of property and equipment | 0 | 0 | 7
Purchases of available-for-sale securities | (484,144) | (8,192) | (411,299)
Proceeds from sales of available-for-sale securities | 4,214 | 10,606 | 0
Proceeds from maturities of investments | 83,144 | 456,900 | 537,072
Net cash provided by (used in) investing activities | (426,972) | 452,487 | 120,018
Financing activities |  |  |
Repayments of finance lease liabilities | (5,489) | (12,620) | (11,925)
Repayments of lease obligations | (403) | (403) | (403)
Cash paid for payroll taxes on restricted stock unit releases | (7,372) | (11,463) | (12,750)
Proceeds from issuance of common stock | 12,701 | 37,829 | 20,778
Net cash provided by (used in) financing activities | (563) | 13,343 | (4,300)
Effect of exchange rate change on cash and cash equivalents | 2,597 | 4,695 | (5)
Net increase (decrease) in cash and cash equivalents | (507,170) | 552,127 | 37,008
Total cash and cash equivalents at beginning of period | 678,393 | 126,266 | 89,258
Total cash and cash equivalents at end of period | 171,223 | 678,393 | 126,266
Supplemental cash flow information: |  |  |
Interest payments | 94 | 135 | 174
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 1,009 | 884 | 460
Balance in accrued liabilities related to acquired in-process research and development asset | 35,000 | 0 | 0
Balance in other receivables related to stock option exercise | 165 | 0 | 0
Conversion of subsidiary's convertible note payable to non-controlling interests | $ 696 | $ 0 | $ 0

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