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Collaboration Agreements,License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 USD ($)
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | $ (2,147)
Balance at December 31, 2021 | (58,909)
AstraZeneca Agreements [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | (137,338)
Additions | (69,746)
Balance at December 31, 2021 | (171,516)
Milestone payment received | 35,568
Product [Member] | Direct Sales [Member] | Contract Liabilities [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | (15,137)
Additions | (1,371)
Deduction | 13,645
Currency Translation and Other | (313)
Balance at December 31, 2021 | (3,176)
Drug Product Revenue [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | (5,984)
Additions | (83,019)
Balance at December 31, 2021 | (39,036)
Milestone payment received | 179
Balance Presented Net Against Contract Asset | 49,788
Drug Product Revenue [Member] | AstraZeneca Agreements [Member] | U.S. [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | 0
Additions | (11,171)
Balance at December 31, 2021 | (11,171)
Milestone payment received | 0
Balance Presented Net Against Contract Asset | 0
Drug Product Revenue [Member] | Astellas Agreement | Japan [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | 0
Additions | (1,974)
Balance at December 31, 2021 | (1,974)
Milestone payment received | 0
Balance Presented Net Against Contract Asset | 0
Drug Product Revenue [Member] | Astellas Agreement | Europe [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2020 | (5,984)
Additions | (69,874)
Balance at December 31, 2021 | (25,891)
Milestone payment received | 179
Balance Presented Net Against Contract Asset | $ 49,788

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- Definition Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=123360276&loc=SL49130531-203044 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 8 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130549-203045 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=123360276&loc=SL49130532-203044 + Details
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