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Related Party Transactions - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Related Party Transaction [Line Items] |  |  |
Accounts receivable from related parties | $ 10,930,000 | $ 4,127,000 |
Deferred revenue | 58,909,000 | 2,147,000 |
Accrued liabilities to related party | 4,000 | 24,000 |
Investment income (loss) | 1,007,000 | (202,000) | $ 0
Equity method investment in unconsolidated variable interest entity | 3,825,000 | 2,728,000 |
Astellas [Member] |  |  |
Related Party Transaction [Line Items] |  |  |
Drug product revenue from a related party | 3,200,000 | 4,300,000 | (36,300,000)
Astellas [Member] | Collaborative Arrangement [Member] |  |  |
Related Party Transaction [Line Items] |  |  |
Expense related to collaboration agreements | 200,000 | 500,000 | 2,800,000
Accounts receivable from related parties | 10,900,000 | 4,100,000 |
Deferred revenue | 27,900,000 | 7,500,000 |
Accrued liabilities to related party |  | 1,100,000 |
Falikang |  |  |
Related Party Transaction [Line Items] |  |  |
Accounts receivable from related parties | 0 |  |
Deferred revenue | $ 1,200,000 |  |
Percentage of outstanding shares owned | 51.10% |  |
Investment income (loss) | $ 1,000,000.0 | (200,000) |
Equity method investment in unconsolidated variable interest entity | 3,800,000 | 2,700,000 |
Miscellaneous receivables | 0 | 900,000 |
Falikang | Collaborative Arrangement [Member] |  |  |
Related Party Transaction [Line Items] |  |  |
Revenue related to collaboration agreements | 35,600,000 |  |
License and Development [Member] | Astellas [Member] | Collaborative Arrangement [Member] |  |  |
Related Party Transaction [Line Items] |  |  |
Revenue related to collaboration agreements | $ 130,400,000 | $ 33,500,000 | $ 158,800,000

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