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Collaboration Agreements,License Agreement and Revenues - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue recognized | $ 235,309 | $ 176,319 | $ 256,577
Unbilled contract asset | 66,909 | 2,147 |
Drug Product Revenue [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue recognized | 962 | 8,906 | (36,324)
Drug Product Revenue [Member] | API Shipment [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue recognized | 2,100 | $ (4,000) | $ (36,300)
Bulk Drug Product | Europe [Member] | E U Supply And Astellas Agreement |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue recognized | 8,300 |  |
Unbilled contract asset | 49,800 |  |
Bulk Drug Product | Astra Zeneca |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Drug product revenue recognized | $ 11,200 |  |

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