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Collaboration Agreements,License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 235,309 | $ 176,319 | $ 256,577
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 58,909 | 2,147 |
Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 47,638 | 72,498 | 1,700
Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Reductions to gross accounts receivable | 13,400 |  |
AstraZeneca Agreements [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 171,516 | 137,338 |
AstraZeneca Agreements [Member] | China [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 0 | (90) | 90
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 10,600 |  |
AstraZeneca Agreements [Member] | China [Member] | Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 35,600 |  |
Contractual Sales Rebate [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 800 | 6,200 | 100
Discounts And Rebates |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 1,700 | 16,400 | 1,100
Discounts And Rebates Current |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 1,000 |  | 900
Non-key Account Hospital Listing Award [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 0 | 9,300 | $ 0
Rebates and Discounts [Member] | Gross Accounts Receivable [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 1,100 | 500 |
Rebates and Discounts [Member] | Contract Liabilities [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 3,200 | $ 15,100 |
Constrained for Future Recognition [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 27,200 |  |

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