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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

		Years Ended December 31,
		2021				2020				2019
Domestic		$	(268,499	)		$	(195,617	)		$	2,538
Foreign			(22,184	)			6,888				(79,180	)
Loss before provision for income taxes		$	(290,683	)		$	(188,729	)		$	(76,642	)

Schedule of Components of Provision For Income Taxes

The provision for income taxes consists of the following (in thousands):

		Years Ended December 31,
		2021				2020				2019
Current:
Federal		$	—			$	—			$	—
State			—				—				—
Foreign			347				360				328
Total current			347				360				328
Deferred:
Federal			—				—				—
State			—				—				—
Foreign			—				—				—
Total deferred			—				—				—
Total provision for income taxes		$	347			$	360			$	328

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

	Years Ended December 31,
	2021				2020				2019
Tax at statutory federal rate		21.0	%			21.0	%			21.0	%
State tax		—	%			—	%			—	%
Stock-based compensation expense		(1.8	)%			2.4	%			6.3	%
Benefit due to intercompany transfer of assets		—	%			41.7	%			—	%
Valuation allowance on intercompany transfer of assets		—	%			(41.7	)%			—	%
Net operating losses not benefitted		(16.8	)%			(23.2	)%			(2.9	)%
Foreign net operating losses not benefitted		(1.6	)%			0.7	%			(21.7	)%
Deduction limitation on executive compensation		(0.3	)%			(0.8	)%			(2.5	)%
Other		(0.6	)%			(0.3	)%			(0.6	)%
Total		(0.1	)%			(0.2	)%			(0.4	)%

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

		December 31,
		2021				2020
Federal and state net operating loss carryforwards		$	167,135			$	134,033
Tax credit carryforwards			78,832				62,465
Foreign net operating loss carryforwards			38,117				32,417
Stock-based compensation			10,050				10,399
Lease obligations			20,415				8,243
Reserves and accruals			6,067				5,875
Deferred revenue			20,101				13,550
Intangible assets			84,625				75,915
Other			825				—
Subtotal			426,167				342,897
Less: Valuation allowance			(409,810	)			(337,824	)
Net deferred tax assets			16,357				5,073
Fixed assets			(16,357	)			(5,073	)
Other			—				—
Net deferred tax liabilities			(16,357	)			(5,073	)
Total net deferred tax assets		$	—			$	—

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2021 is as follows (in thousands):

		Federal and State
Balance as of December 31, 2018		$	27,956
Decrease due to prior positions			(111	)
Increase due to current year position			4,418
Balance as of December 31, 2019			32,263
Decrease due to prior positions			(137	)
Increase due to current year position			16,448
Balance as of December 31, 2020			48,574
Decrease due to prior positions			(245	)
Increase due to current year position			8,415
Foreign exchange rate differential			927
Balance as of December 31, 2021		$	57,671

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