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Collaboration Agreements, License Agreement and Revenues - Summary of Revenue Recognized Under the Collaboration Agreements - Additional Information 4 (Detail)	12 Months Ended
	Dec. 31, 2021 USD ($)
Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Transaction price, variable consideration from estimated future co-development billing	$ 0
Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Transaction price, variable consideration from estimated future co-development billing	12,900,000
Europe [Member] | Astellas Agreement [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Changes in revenue due to prior period adjustment of performance obligations	1,000,000.0
U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Transaction price, variable consideration from estimated future co-development billing	30,900,000
U.S./RoW and China [Member] | AstraZeneca Agreements [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Changes in revenue due to prior period adjustment of performance obligations	$ 4,800,000

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- Definition

Variable consideration payment received from estimated future co-development billing.

+ References

No definition available.

+ Details

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- Definition

Amount of revenue recognized arising from contract liability from change in timeframe for performance obligation to be satisfied.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 10
-Subparagraph (e)
-URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130551-203045

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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