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Collaboration Agreements,License Agreement and Revenues - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	$ 235,309	$ 176,319	$ 256,577
Unbilled contract asset	66,909	2,147
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	962	8,906	(36,324)
Drug Product Revenue [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	2,100	$ (4,000)	$ (36,300)
Bulk Drug Product | Europe [Member] | E U Supply And Astellas Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	8,300
Unbilled contract asset	49,800
Bulk Drug Product | Astra Zeneca
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	$ 11,200

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