Balance Sheet Components - Schedule of Property and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 149,285	$ 144,894
Less: accumulated depreciation	(121,008)	(111,247)
Property and equipment, net	28,277	33,647
Leasehold improvements [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	103,352	102,006
Laboratory Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	19,300	18,143
Machinery [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	8,339	8,312
Computer Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	9,670	9,545
Furniture and Fixtures [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	6,201	6,128
Construction in progress [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 2,423	$ 760

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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