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Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations along with Associated Deferred Revenue (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Deferred Revenue | $ 58,909 | $ 2,147
Astellas Agreement [Member] | Japan [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 116,945 |
Deferred Revenue | 0 |
Total Consideration | 116,945 |
Astellas Agreement [Member] | Japan [Member] | License Revenue [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 100,347 |
Deferred Revenue | 0 |
Total Consideration | 100,347 |
Astellas Agreement [Member] | Japan [Member] | Development Revenue [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 16,598 |
Deferred Revenue | 0 |
Total Consideration | 16,598 |
Astellas Agreement [Member] | Europe [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 867,026 |
Deferred Revenue | 0 |
Total Consideration | 867,026 |
Astellas Agreement [Member] | Europe [Member] | License Revenue [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 596,385 |
Deferred Revenue | 0 |
Total Consideration | 596,385 |
Astellas Agreement [Member] | Europe [Member] | Development Revenue [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 270,641 |
Deferred Revenue | 0 |
Total Consideration | $ 270,641 |

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- Definition Total amount of revenue recognized for license and development services under the collaboration agreement as of a given date. + References No definition available. + Details
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- Definition Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=123360276&loc=SL49130531-203044 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 8 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130549-203045 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=123360276&loc=SL49130532-203044 + Details
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