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Balance Sheet Components (Tables) | 12 Months Ended
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Dec. 31, 2021
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Cash |  | $ | 111,422 |  |  | $ | 88,046 |
Commercial paper |  |  | 1,000 |  |  |  | — |
Money market funds |  |  | 58,801 |  |  |  | 590,347 |
Total cash and cash equivalents |  | $ | 171,223 |  |  | $ | 678,393 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments | The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2021 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 183,136 |  |  | $ | 2 |  |  | $ | (492 | ) |  | $ | 182,646 |
Commercial paper |  |  | 68,079 |  |  |  | — |  |  |  | — |  |  |  | 68,079 |
U.S. government bonds |  |  | 91,840 |  |  |  | — |  |  |  | (318 | ) |  |  | 91,522 |
Agency bonds |  |  | 23,339 |  |  |  | — |  |  |  | (64 | ) |  |  | 23,275 |
Asset-backed securities |  |  | 27,105 |  |  |  | — |  |  |  | (18 | ) |  |  | 27,087 |
Foreign government bonds |  |  | 9,165 |  |  |  | — |  |  |  | (11 | ) |  |  | 9,154 |
Total investments |  | $ | 402,664 |  |  | $ | 2 |  |  | $ | (903 | ) |  | $ | 401,763 |
|  | December 31, 2020 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Bond and mutual funds |  | $ | 8,147 |  |  | $ | — |  |  | $ | (3 | ) |  | $ | 8,144 |
Equity investments |  |  | 125 |  |  |  | 119 |  |  |  | — |  |  |  | 244 |
Total investments |  | $ | 8,272 |  |  | $ | 119 |  |  | $ | (3 | ) |  | $ | 8,388 |
Summary of Contractual Maturities of Available-for-Sale Investments | The contractual maturities of the available-for-sale investments were as follows (in thousands):
|  | December 31, 2021 |
Within one year - Bond and mutual funds |  | $ | 233,967 |
After one year through three years |  |  | 167,796 |
Total investments |  | $ | 401,763 |
Schedule of Inventory | Inventories consisted of the following (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Raw materials |  | $ | 1,363 |  |  | $ | 2,303 |
Work-in-progress |  |  | 21,499 |  |  |  | 8,114 |
Finished goods |  |  | 8,153 |  |  |  | 6,113 |
Total inventories |  | $ | 31,015 |  |  | $ | 16,530 |
Schedule of Prepaid Expenses and Other Current Assets | Prepaid expenses and other current assets consisted of the following (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Unbilled contract assets |  | $ | 66,909 |  |  | $ | 2,147 |
Deferred revenues from associated contracts |  |  | (58,909 | ) |  |  | (2,147 | )
Net unbilled contract assets |  |  | 8,000 |  |  |  | — |
Prepaid assets |  |  | 7,383 |  |  |  | 8,353 |
Other current assets |  |  | 5,070 |  |  |  | 1,807 |
Total prepaid expenses and other current assets |  | $ | 20,453 |  |  | $ | 10,160 |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Leasehold improvements |  | $ | 103,352 |  |  | $ | 102,006 |
Laboratory equipment |  |  | 19,300 |  |  |  | 18,143 |
Machinery |  |  | 8,339 |  |  |  | 8,312 |
Computer equipment |  |  | 9,670 |  |  |  | 9,545 |
Furniture and fixtures |  |  | 6,201 |  |  |  | 6,128 |
Construction in progress |  |  | 2,423 |  |  |  | 760 |
Total property and equipment |  | $ | 149,285 |  |  | $ | 144,894 |
Less: accumulated depreciation |  |  | (121,008 | ) |  |  | (111,247 | )
Property and equipment, net |  | $ | 28,277 |  |  | $ | 33,647 |
Schedule of Accrued and Other Current Liabilities | Accrued and other current liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Preclinical and clinical trial accruals |  | $ | 56,283 |  |  | $ | 44,113 |
Acquired in-process research and development asset |  |  | 35,000 |  |  |  | — |
Payroll and related accruals |  |  | 20,909 |  |  |  | 22,800 |
Contract liabilities to pharmaceutical distributors |  |  | 3,176 |  |  |  | 15,137 |
Accrued co-promotion expenses - current |  |  | 25,746 |  |  |  | 11,537 |
Roxadustat profit share to AstraZeneca |  |  | 7,895 |  |  |  | 7,007 |
Property taxes and other taxes |  |  | 12,610 |  |  |  | 5,970 |
Professional services |  |  | 6,074 |  |  |  | 4,869 |
Other |  |  | 4,895 |  |  |  | 6,900 |
Total accrued and other current liabilities |  | $ | 172,588 |  |  | $ | 118,333 |
Schedule of Other Long-term Liabilities | Other long-term liabilities consisted of the following (in thousands):
|  | December 31, 2021 |  |  | December 31, 2020 |
Accrued long-term co-promotion expenses |  | $ | 15,236 |  |  | $ | 27,424 |
Other long-term tax liabilities |  |  | 9,192 |  |  |  | 8,675 |
Other |  |  | 1,590 |  |  |  | 2,690 |
Total other long-term liabilities |  | $ | 26,018 |  |  | $ | 38,789 |

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