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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2020 | Sep. 30, 2019 | Apr. 30, 2006 | Jun. 30, 2005 | Sep. 30, 2021 | Jun. 30, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Feb. 28, 2009 | Feb. 28, 2009 | Jun. 30, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  | $ 235,309,000 | $ 176,319,000 | $ 256,577,000 |  |  |
Unbilled contract asset | $ 2,147,000 |  |  |  |  |  | 66,909,000 | 2,147,000 |  |  |  |
Deferred Revenue | 6,547,000 |  |  |  |  |  | 15,857,000 | 6,547,000 |  |  |  |
Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  | $ 962,000 | 8,906,000 | (36,324,000) |  |  |
Japan [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  | $ 8,200,000 |  |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  |  |  |  | $ 40,100,000 |
Potential milestone payments | 15,000,000.0 | $ 12,500,000 |  | $ 132,500,000 |  |  |  |  |  |  |  |
Commercial sales milestone |  |  |  | 15,000,000.0 |  |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  |  |  | the low 20% range of the list price |  |  |  |  |
Transaction price and allocated to performance obligations | $ 15,000,000.0 | $ 12,500,000 |  |  |  |  |  | 15,000,000.0 |  |  |  |
Aggregate considerations received excluding drug product revenue |  |  |  |  |  |  | $ 105,100,000 |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  | $ 2,100,000 | $ 4,300,000 | (36,300,000) |  |  |
Astellas Agreement [Member] | Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  | 22,500,000 |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  | $ 95,000,000.0 |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  |  |  | $ 320,000,000.0 |  |
Potential milestone payments |  |  |  |  | $ 120,000.0 |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  |  |  | low 20% range |  |  |  |  |
Transaction price and allocated to performance obligations |  |  |  |  | $ 120,000.0 |  |  |  |  |  |  | $ 130,000,000.0
Aggregate considerations received excluding drug product revenue |  |  |  |  |  |  | $ 660,000,000.0 |  |  |  |  |
Development and regulatory approval milestones |  |  | $ 425,000,000.0 |  |  |  |  |  |  |  |  |
Percentage of joint development costs committed to fund |  |  | 50.00% |  |  |  |  |  |  |  |  |
Revenue related to collaboration agreements |  |  |  |  |  |  |  |  | 128,800,000 |  |  |
Unbilled contract asset |  |  |  |  |  |  |  |  | $ 130,000,000.0 |  |  |
Milestone payment received |  |  |  |  |  | $ 130,000,000.0 |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Burdened manufacturing costs |  |  |  |  |  |  | 1,000,000.0 |  |  |  |  |
Deferred Revenue |  |  |  |  |  |  | $ 25,900,000 |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 90,000,000.0 |  |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 335,000,000.0 |  |  |  |  |  |  |  |  |

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