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Collaboration Agreements, License Agreement and Revenues - Accounting for the AstraZeneca Agreements - Additional Information 3 (Detail) - AstraZeneca Agreements [Member] $ in Millions | 12 Months Ended
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Dec. 31, 2021 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Royalty rate against projected net revenues | 40.00%
Co-development services related to CDK continued over development year | 2024
Measurement Input Discount Rate [Member] | Discounted Cash Flow [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Discount rate applied | 17.5
U.S./RoW and China [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Non-contingent upfront payments received | $ 402.2
Variable consideration related to payments for milestones considered probable of being achieved | 114.0
Variable consideration related to co-development billings | 610.9
Variable consideration related to profit share | $ 7.0

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