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Balance Sheet Components (Tables)

12 Months Ended

Dec. 31, 2021

Organization Consolidation And Presentation Of Financial Statements [Abstract]

Schedule of Cash and Cash Equivalents

Cash and cash equivalents consisted of the following (in thousands):

		December 31,
		2021				2020
Cash		$	111,422			$	88,046
Commercial paper			1,000				—
Money market funds			58,801				590,347
Total cash and cash equivalents		$	171,223			$	678,393

Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments

The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):

		December 31, 2021
		Amortized Cost				Gross Unrealized Holding Gains				Gross Unrealized Holding Losses				Fair Value
Corporate bonds		$	183,136			$	2			$	(492	)		$	182,646
Commercial paper			68,079				—				—				68,079
U.S. government bonds			91,840				—				(318	)			91,522
Agency bonds			23,339				—				(64	)			23,275
Asset-backed securities			27,105				—				(18	)			27,087
Foreign government bonds			9,165				—				(11	)			9,154
Total investments		$	402,664			$	2			$	(903	)		$	401,763
		December 31, 2020
		Amortized Cost				Gross Unrealized Holding Gains				Gross Unrealized Holding Losses				Fair Value
Bond and mutual funds		$	8,147			$	—			$	(3	)		$	8,144
Equity investments			125				119				—				244
Total investments		$	8,272			$	119			$	(3	)		$	8,388

Summary of Contractual Maturities of Available-for-Sale Investments

The contractual maturities of the available-for-sale investments were as follows (in thousands):

		December 31, 2021
Within one year - Bond and mutual funds		$	233,967
After one year through three years			167,796
Total investments		$	401,763

Schedule of Inventory

Inventories consisted of the following (in thousands):

		December 31,
		2021				2020
Raw materials		$	1,363			$	2,303
Work-in-progress			21,499				8,114
Finished goods			8,153				6,113
Total inventories		$	31,015			$	16,530

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):

		December 31,
		2021				2020
Unbilled contract assets		$	66,909			$	2,147
Deferred revenues from associated contracts			(58,909	)			(2,147	)
Net unbilled contract assets			8,000				—
Prepaid assets			7,383				8,353
Other current assets			5,070				1,807
Total prepaid expenses and other current assets		$	20,453			$	10,160

Schedule of Property and Equipment

Property and equipment consisted of the following (in thousands):

		December 31,
		2021				2020
Leasehold improvements		$	103,352			$	102,006
Laboratory equipment			19,300				18,143
Machinery			8,339				8,312
Computer equipment			9,670				9,545
Furniture and fixtures			6,201				6,128
Construction in progress			2,423				760
Total property and equipment		$	149,285			$	144,894
Less: accumulated depreciation			(121,008	)			(111,247	)
Property and equipment, net		$	28,277			$	33,647

Schedule of Accrued and Other Current Liabilities

Accrued and other current liabilities consisted of the following (in thousands):

		December 31,
		2021				2020
Preclinical and clinical trial accruals		$	56,283			$	44,113
Acquired in-process research and development asset			35,000				—
Payroll and related accruals			20,909				22,800
Contract liabilities to pharmaceutical distributors			3,176				15,137
Accrued co-promotion expenses - current			25,746				11,537
Roxadustat profit share to AstraZeneca			7,895				7,007
Property taxes and other taxes			12,610				5,970
Professional services			6,074				4,869
Other			4,895				6,900
Total accrued and other current liabilities		$	172,588			$	118,333

Schedule of Other Long-term Liabilities

Other long-term liabilities consisted of the following (in thousands):

		December 31, 2021				December 31, 2020
Accrued long-term co-promotion expenses		$	15,236			$	27,424
Other long-term tax liabilities			9,192				8,675
Other			1,590				2,690
Total other long-term liabilities		$	26,018			$	38,789

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