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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 235,309	$ 176,319	$ 256,577
License Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	116,434	14,323	177,086
Development Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	70,275	80,592	114,115
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	14,323	11,935
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	108,434	0	117,470
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	248	1,220	1,222
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	21,679	17,954	28,172
AstraZeneca Agreements [Member] | China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	(90)	90
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	0	47,681
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 48,345	$ 61,508	$ 84,629

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- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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