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Collaboration Agreements, License Agreement and Revenues - Deferred Revenue - Additional Information (Detail) - USD ($) $ in Thousands | Mar. 31, 2022 | Dec. 31, 2021
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Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Reductions to gross accounts receivable | $ 8,200 | $ 400
AstraZeneca Agreements [Member] |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Deferred revenue | 171,238 | $ 171,516
AstraZeneca Agreements [Member] | China [Member] |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Deferred revenue | $ 12,600 |

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