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v3.22.1

Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands | 3 Months Ended
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Mar. 31, 2022 USD ($)
AstraZeneca Agreements [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | $ (171,516)
Additions | (15,945)
Recognized as Revenue | 16,223
Balance at March 31, 2022 | (171,238)
Product Revenue, Net [Member] | Direct Sales [Member] | Contract Liabilities [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | (3,176)
Additions | (407)
Deduction | 835
Currency Translation and Other | (11)
Balance at March 31, 2022 | (2,759)
Drug Product Revenue [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | (39,036)
Additions | (51,386)
Reclassified to Accrued Liability | 60,834
Balance at March 31, 2022 | (29,588)
Drug Product Revenue [Member] | AstraZeneca Agreements [Member] | U.S. [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | (11,171)
Reclassified to Accrued Liability | 11,171
Drug Product Revenue [Member] | Astellas Agreement [Member] | Japan [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | (1,974)
Additions | (2,226)
Reclassified to Accrued Liability | 4,200
Drug Product Revenue [Member] | Astellas Agreement [Member] | Europe [Member] |
Contract with Customer Liability [Line Items] |
Balance at December 31, 2021 | (25,891)
Additions | (49,160)
Reclassified to Accrued Liability | 45,463
Balance at March 31, 2022 | $ (29,588)

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