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Balance Sheet Components (Tables) | 3 Months Ended
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Mar. 31, 2022
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | March 31, 2022 |  |  | December 31, 2021 |
Cash |  | $ | 165,436 |  |  | $ | 111,422 |
Commercial paper |  |  | 3,994 |  |  |  | 1,000 |
Money market funds |  |  | 16,466 |  |  |  | 58,801 |
Total cash and cash equivalents |  | $ | 185,896 |  |  | $ | 171,223 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments | The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):
|  | March 31, 2022 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 148,022 |  |  | $ | — |  |  | $ | (1,749 | ) |  | $ | 146,273 |
Commercial paper |  |  | 50,357 |  |  |  | — |  |  |  | — |  |  |  | 50,357 |
U.S. government bonds |  |  | 99,764 |  |  |  | — |  |  |  | (1,388 | ) |  |  | 98,376 |
Agency bonds |  |  | 23,279 |  |  |  | — |  |  |  | (261 | ) |  |  | 23,018 |
Asset-backed securities |  |  | 12,693 |  |  |  | — |  |  |  | (33 | ) |  |  | 12,660 |
Foreign government bonds |  |  | 5,044 |  |  |  | — |  |  |  | (61 | ) |  |  | 4,983 |
Total investments |  | $ | 339,159 |  |  | $ | — |  |  | $ | (3,492 | ) |  | $ | 335,667 |
|  | December 31, 2021 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 183,136 |  |  | $ | 2 |  |  | $ | (492 | ) |  | $ | 182,646 |
Commercial paper |  |  | 68,079 |  |  |  | — |  |  |  | — |  |  |  | 68,079 |
U.S. government bonds |  |  | 91,840 |  |  |  | — |  |  |  | (318 | ) |  |  | 91,522 |
Agency bonds |  |  | 23,339 |  |  |  | — |  |  |  | (64 | ) |  |  | 23,275 |
Asset-backed securities |  |  | 27,105 |  |  |  | — |  |  |  | (18 | ) |  |  | 27,087 |
Foreign government bonds |  |  | 9,165 |  |  |  | — |  |  |  | (11 | ) |  |  | 9,154 |
Total investments |  | $ | 402,664 |  |  | $ | 2 |  |  | $ | (903 | ) |  | $ | 401,763 |
Schedule of Inventory | Inventories consisted of the following (in thousands):
|  | March 31, 2022 |  |  | December 31, 2021 |
Raw materials |  | $ | 1,359 |  |  | $ | 1,363 |
Work-in-progress |  |  | 33,837 |  |  |  | 21,499 |
Finished goods |  |  | 7,871 |  |  |  | 8,153 |
Total inventories |  | $ | 43,067 |  |  | $ | 31,015 |
Schedule of Accrued and Other Current Liabilities | Accrued and other current liabilities consisted of the following (in thousands):
|  | March 31, 2022 |  |  | December 31, 2021 |
Preclinical and clinical trial accruals |  | $ | 65,112 |  |  | $ | 56,283 |
API and bulk drug product price true-up |  |  | 60,834 |  |  |  | — |
Acquired in-process research and development asset |  |  | — |  |  |  | 35,000 |
Payroll and related accruals |  |  | 12,325 |  |  |  | 20,909 |
Contract liabilities to pharmaceutical distributors |  |  | 2,759 |  |  |  | 3,176 |
Accrued co-promotion expenses - current |  |  | 28,117 |  |  |  | 25,746 |
Roxadustat profit share to AstraZeneca |  |  | 7,917 |  |  |  | 7,895 |
Property taxes and other taxes |  |  | 13,928 |  |  |  | 12,610 |
Professional services |  |  | 6,819 |  |  |  | 6,074 |
Other |  |  | 5,488 |  |  |  | 4,906 |
Total accrued and other current liabilities |  | $ | 203,299 |  |  | $ | 172,599 |

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