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Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Detail) - USD ($) $ in Thousands | Mar. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Accrued Liabilities Current [Abstract] |  |
Preclinical and clinical trial accruals | $ 65,112 | $ 56,283
API and bulk drug product price true-up | 60,834 |
Acquired in-process research and development asset |  | 35,000
Payroll and related accruals | 12,325 | 20,909
Contract liabilities to pharmaceutical distributors | 2,759 | 3,176
Accrued co-promotion expenses - current | 28,117 | 25,746
Roxadustat profit share to AstraZeneca | 7,917 | 7,895
Property taxes and other taxes | 13,928 | 12,610
Professional services | 6,819 | 6,074
Other | 5,488 | 4,906
Total accrued and other current liabilities | $ 203,299 | $ 172,599

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- Definition Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to pre-clinical and clinical trial activities, including those performed by third parties. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References No definition available. + Details
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