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Collaboration Agreements, License Agreement and Revenues - Deferred Revenue - Additional Information (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Reductions to gross accounts receivable	$ 8,200	$ 400
AstraZeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue	171,238	$ 171,516
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue	$ 12,600

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