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Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Accrued Liabilities Current [Abstract]
Preclinical and clinical trial accruals	$ 65,112	$ 56,283
API and bulk drug product price true-up	60,834
Acquired in-process research and development asset		35,000
Payroll and related accruals	12,325	20,909
Contract liabilities to pharmaceutical distributors	2,759	3,176
Accrued co-promotion expenses - current	28,117	25,746
Roxadustat profit share to AstraZeneca	7,917	7,895
Property taxes and other taxes	13,928	12,610
Professional services	6,819	6,074
Other	5,488	4,906
Total accrued and other current liabilities	$ 203,299	$ 172,599

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Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to pre-clinical and clinical trial activities, including those performed by third parties. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Acquired in process research and development asset.

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Property taxes and other current.

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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Amount of expenses incurred but not yet paid classified as other, due within one year or the normal operating cycle, if longer.

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