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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | ---
Apr. 30, 2006 | Jun. 30, 2005 | Sep. 30, 2022 | Mar. 31, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Total revenue |  |  | $ 15,735,000 |  | $ 155,973,000 | $ 106,367,000 | $ 218,766,000 |
Deferred Revenue |  |  | 7,361,000 |  |  | 7,361,000 |  | $ 15,857,000
Drug Product Revenue [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Total revenue |  |  | 4,077,000 |  | $ 0 | 4,610,000 | $ (168,000) |
Japan [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Transaction price, variable consideration from estimated future co-development billing |  |  |  |  |  | 0 |  |
Japan [Member] | Drug Product Revenue [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Total revenue |  |  |  | $ 9,800,000 |  |  |  |
Europe [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Transaction price, variable consideration from estimated future co-development billing |  |  |  |  |  | $ 6,300,000 |  |
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  | $ 172,600,000 |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  |  | the low 20% range of the list price |  |
Aggregate consideration received excluding drug product revenue |  |  | 105,100,000 |  |  | $ 105,100,000 |  |
Revenue resulting from changes to estimated variable consideration |  |  | 0 |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received | $ 745,000,000.0 |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  |  | low 20% range |  |
Aggregate consideration received excluding drug product revenue |  |  | 685,000,000.0 |  |  | $ 685,000,000.0 |  |
Percentage of joint development costs committed to fund | 50.00% |  |  |  |  |  |  |
Transaction price and allocated to performance obligations |  |  |  | $ 25,000,000.0 |  |  |  |
Changes in revenue from changes to estimated variable consideration |  |  | $ 0 |  |  |  |  |

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