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Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2022 | Jun. 30, 2022 | Mar. 31, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Deferred Revenue | $ 7,361 |  |  |  | $ 7,361 |  | $ 15,857
Drug product revenue recognized | 15,735 |  |  | $ 155,973 | 106,367 | $ 218,766 |
Royalty Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue | 200 |  |  |  | 300 |  |
Astra Zeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue |  |  |  |  | 50,873 |  |
Drug Product Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 4,077 |  |  | 0 | 4,610 | (168) |
Drug Product Revenue [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 236 |  |  | 0 | 1,313 | 0 |
Drug Product Revenue [Member] | Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  | $ 9,800 |  |  |  |
Drug Product Revenue [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 4,313 |  |  | $ 0 | 3,297 | 2,056 |
Drug Product Revenue [Member] | API Shipment [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | (4,300) |  |  |  |  | $ 2,100 |
Drug Product Revenue [Member] | API Shipment [Member] | Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  | 2,200 |  |  |  |
Bulk Drug Product [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 51,000 |  |
Accrued liabilities | 51,000 |  |  |  | 51,000 |  |
Bulk Drug Product [Member] | Astra Zeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 11,200 |  |
Accrued liabilities | $ 11,200 |  |  |  | $ 11,200 |  |
Bulk Drug Product [Member] | E U Supply And Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Deferred Revenue |  | $ 23,200 |  |  |  |  |
Billed Contracts Receivable |  |  | $ 49,200 |  |  |  |
Burdened manufacturing costs |  | $ 1,000 |  |  |  |  |

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