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v3.22.2.2

Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Operating activities |  |
Net loss | $ (227,479) | $ (155,945)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 7,503 | 7,717
Amortization of finance lease right-of-use assets | 411 | 4,509
Net accretion of premium and discount on investments | 1,842 | 1,447
Unrealized loss on equity investments | 0 | 12
Investment income in unconsolidated variable interest entity | (1,293) | (664)
(Gain) / loss on disposal of property and equipment | (3) | 232
Stock-based compensation | 49,377 | 54,089
Expense for acquired in-process research and development asset | 0 | 25,000
Realized loss on sales of available-for-sale securities | 5 | 8
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 983 | 6,131
Inventories | (11,147) | (12,658)
Prepaid expenses and other current assets | 8,265 | (11,160)
Operating lease right-of-use assets | 7,759 | 1,232
Other assets | 823 | (3,563)
Accounts payable | (5,120) | (1,115)
Accrued and other liabilities | 87,167 | 31,997
Operating lease liabilities, current | 715 | 410
Deferred revenue | 4,509 | 40,650
Accrued interest for finance lease liabilities | (68) | (76)
Operating lease liabilities, non-current | (7,407) | (1,326)
Other long-term liabilities | (10,262) | (14,199)
Net cash used in operating activities | (93,420) | (27,272)
Investing activities |  |
Purchases of property and equipment | (3,408) | (3,790)
Payment made for acquired in-process research and development asset | (35,000) | (25,000)
Proceeds from sale of property and equipment | 8 | 0
Purchases of available-for-sale securities | (97,301) | (397,909)
Proceeds from sales of available-for-sale securities | 7,382 | 4,000
Proceeds from maturities of investments | 216,342 | 46,294
Net cash provided by (used in) investing activities | 88,023 | (376,405)
Financing activities |  |
Repayments of finance lease liabilities | (23) | (5,359)
Repayments of lease obligations | (302) | (302)
Cash paid for payroll taxes on restricted stock unit releases | (4,562) | (6,734)
Proceeds from issuance of common stock | 2,989 | 11,863
Net cash used in financing activities | (1,898) | (532)
Effect of exchange rate change on cash and cash equivalents | (7,968) | 343
Net increase (decrease) in cash and cash equivalents | (15,263) | (403,866)
Total cash and cash equivalents at beginning of period | 171,223 | 678,393
Total cash and cash equivalents at end of period | $ 155,960 | $ 274,527

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