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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended			9 Months Ended
	Apr. 30, 2006	Jun. 30, 2005	Sep. 30, 2022	Mar. 31, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 15,735,000		$ 155,973,000	$ 106,367,000	$ 218,766,000
Deferred Revenue			7,361,000			7,361,000		$ 15,857,000
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			4,077,000		$ 0	4,610,000	$ (168,000)
Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing						0
Japan [Member] | Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue				$ 9,800,000
Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing						$ 6,300,000
Astellas Agreement [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received		$ 172,600,000
Additional consideration based on net sales description						the low 20% range of the list price
Aggregate consideration received excluding drug product revenue			105,100,000			$ 105,100,000
Revenue resulting from changes to estimated variable consideration			0
Astellas Agreement [Member] | Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received	$ 745,000,000.0
Additional consideration based on net sales description						low 20% range
Aggregate consideration received excluding drug product revenue			685,000,000.0			$ 685,000,000.0
Percentage of joint development costs committed to fund	50.00%
Transaction price and allocated to performance obligations				$ 25,000,000.0
Changes in revenue from changes to estimated variable consideration			$ 0

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The amount of additional consideration based on net sales of product as defined under a collaboration agreement.

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Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs.

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Transaction price allocated to performance obligations.

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Amount of revenue recognized arising from contract liability from change in timeframe for performance obligation to be satisfied.

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