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Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Operating activities    
Net loss $ (227,479) $ (155,945)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 7,503 7,717
Amortization of finance lease right-of-use assets 411 4,509
Net accretion of premium and discount on investments 1,842 1,447
Unrealized loss on equity investments 0 12
Investment income in unconsolidated variable interest entity (1,293) (664)
(Gain) / loss on disposal of property and equipment (3) 232
Stock-based compensation 49,377 54,089
Expense for acquired in-process research and development asset 0 25,000
Realized loss on sales of available-for-sale securities 5 8
Changes in operating assets and liabilities:    
Accounts receivable, net 983 6,131
Inventories (11,147) (12,658)
Prepaid expenses and other current assets 8,265 (11,160)
Operating lease right-of-use assets 7,759 1,232
Other assets 823 (3,563)
Accounts payable (5,120) (1,115)
Accrued and other liabilities 87,167 31,997
Operating lease liabilities, current 715 410
Deferred revenue 4,509 40,650
Accrued interest for finance lease liabilities (68) (76)
Operating lease liabilities, non-current (7,407) (1,326)
Other long-term liabilities (10,262) (14,199)
Net cash used in operating activities (93,420) (27,272)
Investing activities    
Purchases of property and equipment (3,408) (3,790)
Payment made for acquired in-process research and development asset (35,000) (25,000)
Proceeds from sale of property and equipment 8 0
Purchases of available-for-sale securities (97,301) (397,909)
Proceeds from sales of available-for-sale securities 7,382 4,000
Proceeds from maturities of investments 216,342 46,294
Net cash provided by (used in) investing activities 88,023 (376,405)
Financing activities    
Repayments of finance lease liabilities (23) (5,359)
Repayments of lease obligations (302) (302)
Cash paid for payroll taxes on restricted stock unit releases (4,562) (6,734)
Proceeds from issuance of common stock 2,989 11,863
Net cash used in financing activities (1,898) (532)
Effect of exchange rate change on cash and cash equivalents (7,968) 343
Net increase (decrease) in cash and cash equivalents (15,263) (403,866)
Total cash and cash equivalents at beginning of period 171,223 678,393
Total cash and cash equivalents at end of period $ 155,960 $ 274,527