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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 140,734 | $ 235,309 | $ 176,319
License Revenue [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 22,590 | 116,434 | 14,323
Development Revenue [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 24,189 | 70,275 | 80,592
Development Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 9,624 | 21,679 | 17,954
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 0 | 14,323
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 22,590 | 108,434 | 0
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 284 | 248 | 1,220
AstraZeneca Agreements [Member] | China [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 0 | (90)
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 0 | 0
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 12,519 | $ 48,345 | $ 61,508

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