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Income Taxes - Schedule of Significant Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Components of Deferred Tax Assets and Liabilities [Abstract] |  |
Federal and state net operating loss carryforwards | $ 166,708 | $ 167,135
Tax credit carryforwards | 106,131 | 78,832
Foreign net operating loss carryforwards | 49,990 | 38,117
Capitalized research and development expenses | 45,125 | 0
Stock-based compensation | 8,616 | 10,050
Lease obligations | 18,442 | 20,415
Reserves and accruals | 4,929 | 6,067
Deferred revenue | 21,624 | 20,101
Intangible assets | 69,159 | 84,625
Other | 1,277 | 825
Subtotal | 492,001 | 426,167
Less: Valuation allowance | (477,969) | (409,810)
Net deferred tax assets | 14,032 | 16,357
Fixed assets | (13,101) | (16,357)
Non-deductibale accrued expenses | (931) | 0
Net deferred tax liabilities | (14,032) | (16,357)
Total net deferred tax assets | $ 0 | $ 0

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