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v3.22.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Operating activities |  |  |
Net loss | $ (293,654) | $ (290,023) | $ (189,291)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation | 10,017 | 10,170 | 11,678
Amortization of finance lease right-of-use assets | 587 | 4,639 | 10,369
Net accretion of premium and discount on investments | 1,619 | 2,482 | 103
Unrealized loss on equity investments | 0 | 30 | 0
Investment income in unconsolidated variable interest entity | (1,573) | (1,007) | 202
(Gain) / loss on disposal of property and equipment | (1) | 233 | 933
Stock-based compensation | 65,601 | 71,161 | 72,720
Expense for acquired in-process research and development asset | 0 | 60,000 | 0
Non-cash interest expense related to sale of future revenues | 1,036 |  |
Realized loss on sales of available-for-sale securities | 5 | 0 | 258
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net ($(1,158), $(6,803) and $718 from related parties) | 765 | 25,180 | (11,973)
Inventories | (10,999) | (14,158) | (9,175)
Prepaid expenses and other current assets ($0, $889 and $124,321 from a related party) | 4,916 | (9,854) | 123,492
Operating lease right-of-use assets | 10,908 | 4,209 | (24)
Other assets | 263 | (4,412) | 5,843
Accounts payable ($0, $(1,118) and $1,118 from a related party) | 5,909 | 805 | 17,731
Accrued and other liabilities ($63,882, $(20) and $(36,859) from a related party) | 90,556 | 16,380 | 30,914
Operating lease liabilities, current | (547) | 503 | 134
Deferred revenue ($11,211, $21,549 and $7,169 from related parties) | (4,130) | 57,637 | 45,077
Accrued interest for finance lease liabilities | 33 | (75) | (177)
Operating lease liabilities, non-current | (8,994) | (4,043) | (143)
Other long-term liabilities | (18,250) | (12,089) | (27,069)
Net cash provided by (used in) operating activities | (145,933) | (82,232) | 81,602
Investing activities |  |  |
Purchases of property and equipment | (3,741) | (5,186) | (3,994)
Payment made for acquired in-process research and development asset | (35,000) | (25,000) | 0
Payment made for investment in unconsolidated variable interest entity | 0 | 0 | (3,896)
Proceeds from equity transfer of unconsolidated variable interest entity | 0 | 0 | 1,063
Proceeds from sale of property and equipment | 6 | 0 | 0
Purchases of available-for-sale securities | (164,023) | (484,144) | (8,192)
Proceeds from sales of available-for-sale securities | 7,382 | 4,214 | 10,606
Proceeds from maturities of investments | 284,492 | 83,144 | 456,900
Net cash provided by (used in) investing activities | 89,116 | (426,972) | 452,487
Financing activities |  |  |
Repayments of finance lease liabilities | (135) | (5,489) | (12,620)
Repayments of lease obligations | (403) | (403) | (403)
Cash paid for payroll taxes on restricted stock unit releases | (5,167) | (7,372) | (11,463)
Proceeds from sale of future revenues, net of issuance costs | 49,750 |  |
Cash paid for transaction costs related to sale of future revenues | (1,453) |  |
Proceeds from issuance of common stock | 4,184 | 12,701 | 37,829
Net cash provided by (used in) financing activities | 46,776 | (563) | 13,343
Effect of exchange rate change on cash and cash equivalents | (5,482) | 2,597 | 4,695
Net increase (decrease) in cash and cash equivalents | (15,523) | (507,170) | 552,127
Total cash and cash equivalents at beginning of period | 171,223 | 678,393 | 126,266
Total cash and cash equivalents at end of period | 155,700 | 171,223 | 678,393
Supplemental Cash Flow Information [Abstract] |  |  |
Interest payments | 104 | 94 | 135
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 428 | 1,009 | 884
Balance in accrued liabilities related to acquired in-process research and development asset | 0 | 35,000 | 0
Balance in other receivables related to stock option exercise | 0 | 165 | 0
Conversion of subsidiary's convertible note payable to non-controlling interests | $ 0 | $ 696 | $ 0

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