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Collaboration Agreements,License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 140,734 | $ 235,309 | $ 176,319
Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 82,869 | 47,638 | 72,498
Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Reductions to gross accounts receivable | 500 | 13,400 |
China [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Recognized as Revenue | 2,300 |  |
China [Member] | Product Revenue, Net [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Contract with customer liability increase decrease in revenue due to changes to estimated variable consideration | 1,400 |  |
AstraZeneca Agreements [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 175,646 | 171,516 |
Recognized as Revenue | 71,167 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 0 | 0 | (90)
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 21,000 |  |
Contractual Sales Rebate [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 600 | 800 | 6,200
Discounts And Rebates |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 700 | 1,700 | 16,400
Discounts And Rebates Current |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue |  | 1,000 |
Non-key Account Hospital Listing Award [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue |  |  | $ 9,300
Rebates and Discounts [Member] | Gross Accounts Receivable [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 900 | 1,100 |
Constrained for Future Recognition [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue |  | $ 27,200 |

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