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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

		Years Ended December 31,
		2022				2021				2020
Domestic		$	(307,056	)		$	(268,499	)		$	(195,617	)
Foreign			12,187				(22,184	)			6,888
Loss before provision for income taxes		$	(294,869	)		$	(290,683	)		$	(188,729	)

Schedule of Components of Provision For Income Taxes

The provision for income taxes consists of the following (in thousands):

		Years Ended December 31,
		2022				2021				2020
Current:
Federal		$	—			$	—			$	—
State			—				—				—
Foreign			358				347				360
Total current			358				347				360
Deferred:
Federal			—				—				—
State			—				—				—
Foreign			—				—				—
Total deferred			—				—				—
Total provision for income taxes		$	358			$	347			$	360

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

	Years Ended December 31,
	2022				2021				2020
Tax at statutory federal rate		21.0	%			21.0	%			21.0	%
State tax		—	%			—	%			—	%
Stock-based compensation expense		(2.5	)%			(1.8	)%			2.4	%
Benefit due to intercompany transfer of assets		—	%			—	%			41.7	%
Valuation allowance on intercompany transfer of assets		—	%			—	%			(41.7	)%
Net operating losses not benefitted		(16.3	)%			(16.8	)%			(23.2	)%
Foreign net operating losses not benefitted		0.9	%			(1.6	)%			0.7	%
Deduction limitation on executive compensation		(0.2	)%			(0.3	)%			(0.8	)%
Global intangible low-taxed income		(2.8	)%			(0.4	)%			—	%
Other		(0.2	)%			(0.2	)%			(0.3	)%
Total		(0.1	)%			(0.1	)%			(0.2	)%

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

		December 31,
		2022				2021
Federal and state net operating loss carryforwards		$	166,708			$	167,135
Tax credit carryforwards			106,131				78,832
Foreign net operating loss carryforwards			49,990				38,117
Capitalized research and development expenses			45,125				—
Stock-based compensation			8,616				10,050
Lease obligations			18,442				20,415
Reserves and accruals			4,929				6,067
Deferred revenue			21,624				20,101
Intangible assets			69,159				84,625
Other			1,277				825
Subtotal			492,001				426,167
Less: Valuation allowance			(477,969	)			(409,810	)
Net deferred tax assets			14,032				16,357
Fixed assets			(13,101	)			(16,357	)
Non-deductibale accrued expenses			(931	)			—
Net deferred tax liabilities			(14,032	)			(16,357	)
Total net deferred tax assets		$	—			$	—

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2022 is as follows (in thousands):

		Federal and State
Balance as of December 31, 2019		$	32,263
Decrease due to prior positions			(137	)
Increase due to current year position			16,448
Balance as of December 31, 2020			48,574
Decrease due to prior positions			(245	)
Increase due to current year position			8,415
Foreign exchange rate differential			927
Balance as of December 31, 2021			57,671
Increase due to prior positions			6,954
Increase due to current year position			9,074
Foreign exchange rate differential			(908	)
Balance as of December 31, 2022		$	72,791

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