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Summary of Significant Accounting Policies - Additional Information (Detail)
 12 Months Ended
Jun. 16, 2021
USD ($)
Dec. 31, 2022
USD ($)
Segment
Dec. 31, 2021
USD ($)
Accounting Policy [Line Items]      
Number of operating segment | Segment   1  
Highly liquid investment maturity period   three months or less  
Restricted time deposits   $ 2,100,000 $ 2,100,000
Cash and cash equivalents   $ 155,700,000 171,223,000
Short term investments maturity   12 months  
Long term Investments Maturity   12 months  
Impairment of long-lived assets   $ 0 0
Impairment of inatangible assets finite lived   $ 0 0
Description of payment term   The period between the transfer of control of the promised goods and when the Company receives payment is based on 60-day payment terms.  
Description of sales return   Distributors can request to return product to the Company only due to quality issues or for product purchased within one year prior to the product’s expiration date.  
Accumulated deficit   $ (1,557,688,000) (1,264,034,000)
Accumulated other comprehensive loss   $ (5,720,000) (4,163,000)
AstraZeneca Agreements [Member]      
Accounting Policy [Line Items]      
Profit share percent   50.00%  
HiFiBiO Agreement [Member]      
Accounting Policy [Line Items]      
Initial upfront payment $ 25,000,000.0    
Maximum additional future clinical, regulatory, and commercial milestone payments $ 345,000,000    
HiFiBiO Agreement [Member] | IPR&D Asset [Member]      
Accounting Policy [Line Items]      
Initial upfront payment     60,000,000.0
HiFiBiO Agreement [Member] | Accrued Liabilities      
Accounting Policy [Line Items]      
Initial upfront payment     35,000,000.0
Minimum [Member] | Computer Equipment [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   3 years  
Minimum [Member] | Laboratory Equipment [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   3 years  
Minimum [Member] | Machinery [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   3 years  
Minimum [Member] | Furniture and Fixtures [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   3 years  
Maximum [Member] | Computer Equipment [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   5 years  
Maximum [Member] | Laboratory Equipment [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   5 years  
Maximum [Member] | Machinery [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   5 years  
Maximum [Member] | Furniture and Fixtures [Member]      
Accounting Policy [Line Items]      
Property and equipment estimated useful life   5 years  
Foreign subsidiaries [Member]      
Accounting Policy [Line Items]      
Cash and cash equivalents   $ 92,500,000 $ 91,200,000
Accounts Receivable from Distributors [Member] | Credit Concentration Risk [Member] | Roxadustat [Member]      
Accounting Policy [Line Items]      
Concentration risk, percentage   10.00%