The amount of additional consideration based on net sales of product as defined under a collaboration agreement.

No definition available.

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- Definition

Amount of aggregate consideration receivable under collaborative arrangement excluding drug product revenue.

+ References

No definition available.

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- Definition

Represents the amount of milestone payments related to commercial sales under the collaborative agreement.

+ References

No definition available.

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- Definition

Represents the potential amount of milestone payments related to development and regulatory approval under the collaborative agreement.

+ References

No definition available.

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- Definition

Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs.

+ References

No definition available.

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- Definition

Represents the total potential amount of milestone payments related to development, regulatory approval and commercial sales under the collaborative agreement.

+ References

No definition available.

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- Definition

Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration.

+ References

No definition available.

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- Definition

Transaction price allocated to performance obligations.

+ References

No definition available.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable, classified as current.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Amount of consideration paid in advance for supplies that provide economic benefits within a future period of one year or the normal operating cycle, if longer.

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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($)	1 Months Ended			3 Months Ended			12 Months Ended			35 Months Ended	45 Months Ended
	Dec. 31, 2020	Apr. 30, 2006	Jun. 30, 2005	Dec. 31, 2022	Mar. 31, 2022	Sep. 30, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Feb. 28, 2009	Feb. 28, 2009
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue							$ 140,734,000	$ 235,309,000	$ 176,319,000
Unbilled contract asset				$ 17,488,000			17,488,000	66,909,000
Deferred Revenue				12,739,000			12,739,000	15,857,000
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue							11,086,000	$ 962,000	8,906,000
Japan [Member] \| Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue				8,400,000	$ 9,800,000		$ 8,200,000
Astellas Agreement [Member] \| Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received											$ 40,100,000
Potential milestone payments	$ 15,000,000.0		$ 132,500,000
Commercial sales milestone			15,000,000.0
Additional consideration based on net sales description							the low 20% range of the list price
Transaction price and allocated to performance obligations	$ 15,000,000.0								$ 15,000,000.0
Aggregate considerations received excluding drug product revenue				105,100,000			$ 105,100,000
Astellas Agreement [Member] \| Japan [Member] \| Clinical and Development Milestone [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments			22,500,000
Astellas Agreement [Member] \| Japan [Member] \| Regulatory Milestone [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments			$ 95,000,000.0
Astellas Agreement [Member] \| Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received										$ 320,000,000.0
Potential milestone payments						$ 120,000.0
Additional consideration based on net sales description							low 20% range
Transaction price and allocated to performance obligations					$ 25,000,000.0	$ 120,000.0
Aggregate considerations received excluding drug product revenue				$ 685,000,000.0			$ 685,000,000.0
Development and regulatory approval milestones		$ 425,000,000.0
Percentage of joint development costs committed to fund		50.00%
Astellas Agreement [Member] \| Europe [Member] \| Clinical and Development Milestone [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments		$ 90,000,000.0
Astellas Agreement [Member] \| Europe [Member] \| Regulatory Milestone [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments		$ 335,000,000.0