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Collaboration Agreements,License Agreement and Revenues - Drug Product Revenue - Summary of Drug Product Revenue (Detail) - USD ($) $ in Thousands	3 Months Ended		12 Months Ended
	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			$ 140,734	$ 235,309	$ 176,319
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			11,086	962	8,906
Drug Product Revenue [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue	$ 8,400	$ 9,800	8,200
Drug Product Revenue [Member] | Astellas Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			11,100
Drug Product Revenue [Member] | Astellas Agreement | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			9,480	2,056	4,281
Drug Product Revenue [Member] | Astellas Agreement | Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			1,606	1,130	0
Drug Product Revenue [Member] | AstraZeneca Agreements [Member] | United States [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue			$ 0	$ (2,224)	$ 4,625

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