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Collaboration Agreements,License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($)	3 Months Ended				12 Months Ended
	Dec. 31, 2022	Jun. 30, 2022	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					$ 140,734,000	$ 235,309,000	$ 176,319,000
Deferred Revenue	$ 12,739,000				12,739,000	15,857,000
Prepaid Supplies	17,488,000				17,488,000	66,909,000
Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Recognized as Revenue					71,167,000
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					11,086,000	962,000	8,906,000
Drug Product Revenue [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					(4,000,000.0)	2,100,000
Drug Product Revenue [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					11,100,000
Drug Product Revenue [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	8,400,000		$ 9,800,000		8,200,000
Accrued liabilities	6,500,000				6,500,000
Drug Product Revenue [Member] | Japan [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					8,700,000
Drug Product Revenue [Member] | Japan [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					9,480,000	2,056,000	4,281,000
Drug Product Revenue [Member] | Europe [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					1,606,000	1,130,000	0
Drug Product Revenue [Member] | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Burdened manufacturing costs		$ 1,000,000.0		$ 1,000,000.0
Bulk Drug Product | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred Revenue						8,300,000
Bulk Drug Product | Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					11,200,000	11,200,000
Accrued liabilities	11,200,000				11,200,000	2,200,000	4,600,000
Bulk Drug Product | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					57,400,000
Deferred Revenue	23,200,000				23,200,000	11,800,000	$ 6,000,000.0
Prepaid Supplies						49,800,000
Billed Contracts Receivable	49,200,000				49,200,000
Accrued liabilities	$ 57,400,000				57,400,000
Bulk Drug Product | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Recognized as Revenue					$ 600	$ 200

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