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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 140,734	$ 235,309	$ 176,319
License Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	22,590	116,434	14,323
Development Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	24,189	70,275	80,592
Development Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	9,624	21,679	17,954
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	0	14,323
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	22,590	108,434	0
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	284	248	1,220
AstraZeneca Agreements [Member] | China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	0	(90)
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	0	0
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 12,519	$ 48,345	$ 61,508

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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