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Collaboration Agreements,License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	$ 140,734	$ 235,309	$ 176,319
Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	82,869	47,638	72,498
Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd
Contract with Customer, Liability [Abstract]
Reductions to gross accounts receivable	500	13,400
China [Member]
Contract with Customer, Liability [Abstract]
Recognized as Revenue	2,300
China [Member] | Product Revenue, Net [Member]
Contract with Customer, Liability [Abstract]
Contract with customer liability increase decrease in revenue due to changes to estimated variable consideration	1,400
AstraZeneca Agreements [Member]
Contract with Customer, Liability [Abstract]
Deferred Revenue	175,646	171,516
Recognized as Revenue	71,167
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	0	0	(90)
Contract with Customer, Liability [Abstract]
Deferred Revenue	21,000
Contractual Sales Rebate [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	600	800	6,200
Discounts And Rebates
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	700	1,700	16,400
Discounts And Rebates Current
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		1,000
Non-key Account Hospital Listing Award [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 9,300
Rebates and Discounts [Member] | Gross Accounts Receivable [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	$ 900	1,100
Constrained for Future Recognition [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		$ 27,200

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