Collaboration Agreements,License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands	12 Months Ended
Dec. 31, 2022 USD ($)
AstraZeneca Agreements [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	$ (171,516)
Additions	(77,195)
Currency Translation and Other	1,898
Recognized as Revenue	71,167
Balance at December 31, 2022	(175,646)
Product [Member] \| Direct Sales [Member] \| Contract Liabilities [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	(3,176)
Additions	(653)
Deduction	3,222
Currency Translation and Other	217
Balance at December 31, 2022	(390)
Drug Product Revenue [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	(39,036)
Additions	(74,634)
Recognized as Revenue	619
Reclassified to accrued liability / accounts payable	72,748
Balance at December 31, 2022	(40,303)
Drug Product Revenue [Member] \| AstraZeneca Agreements [Member] \| U.S. [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	(11,171)
Additions	0
Recognized as Revenue	0
Reclassified to accrued liability / accounts payable	11,171
Balance at December 31, 2022	0
Drug Product Revenue [Member] \| Astellas Agreement \| Japan [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	(1,974)
Additions	(2,226)
Recognized as Revenue	0
Reclassified to accrued liability / accounts payable	4,200
Balance at December 31, 2022	0
Drug Product Revenue [Member] \| Astellas Agreement \| Europe [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2021	(25,891)
Additions	(72,408)
Recognized as Revenue	619
Reclassified to accrued liability / accounts payable	57,377
Balance at December 31, 2022	$ (40,303)

Contract with customer liability additions.

No definition available.

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Contract with customer liability deduction.

+ References

No definition available.

+ Details

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Balance Type:	credit
Period Type:	duration

- Definition

Contract with customer, liability, increase (decrease) from current translation and other.

+ References

No definition available.

+ Details

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Balance Type:	credit
Period Type:	duration

- Definition

Contract with customer liability.

+ References

No definition available.

+ Details

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Balance Type:	na
Period Type:	duration

- Definition

Contract with customer liability reclassified to accrued liability.

+ References

No definition available.

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=126919976&loc=SL49130531-203044

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130549-203045

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=126919976&loc=SL49130532-203044

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130549-203045

+ Details

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Balance Type:	credit
Period Type:	duration

- Details

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- Details

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- Details

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- Details

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Data Type:	na
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Name:	srt_StatementGeographicalAxis=srt_EuropeMember
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