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v3.23.1

Collaboration Agreements, License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 36,161 | $ 60,827 |
Constrained for Future Recognition [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 2,100 | 2,300 |
Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 24,161 | 18,881 |
China [Member] | Product Revenue, Net [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Contract with customer liability increase decrease in revenue due to changes to estimated variable consideration | 300 |  |
AstraZeneca Agreements [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 175,326 |  | $ 175,646
AstraZeneca Agreements [Member] | China [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 22,500 |  |
Beijing Falikang Pharmaceutical Co Ltd | Product Revenue, Net [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Reductions to gross accounts receivable | $ 2,200 | $ 500 |

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