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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended
	Apr. 30, 2006	Jun. 30, 2005	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 36,161,000	$ 60,827,000
Deferred Revenue			16,495,000		$ 12,739,000
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			2,109,000	7,594,000
Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing			0
Japan [Member] | Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 1,700,000	9,800,000
Astellas Agreement [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received		$ 172,600,000
Additional consideration based on net sales description			the low 20% range of the list price
Aggregate consideration received excluding drug product revenue			$ 105,100,000
Changes in revenue from changes to estimated variable consideration			$ 0
Astellas Agreement [Member] | Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received	$ 745,000,000.0
Additional consideration based on net sales description			low 20% range
Aggregate consideration received excluding drug product revenue			$ 685,000,000.0
Transaction price, variable consideration from estimated future co-development billing			5,800,000
Percentage of joint development costs committed to fund	50.00%
Transaction price and allocated to performance obligations				$ 25,000,000.0
Changes in revenue from changes to estimated variable consideration			$ 0

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Amount of aggregate consideration receivable under collaborative arrangement excluding drug product revenue.

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Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration.

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Amount of revenue recognized arising from contract liability from change in timeframe for performance obligation to be satisfied.

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