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Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands	3 Months Ended
	Mar. 31, 2023 USD ($)
AstraZeneca Agreements [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2022	$ (175,646)
Additions	(20,889)
Currency Translation and Other	163
Recognized as Revenue	21,372
Balance at March 31, 2022	(175,326)
Drug Product Revenue [Member] | Astellas Agreement [Member] | Europe [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2022	(40,303)
Additions	0
Reclassified to Accrued Liability	16,552
Recognized as Revenue	377
Balance at March 31, 2022	$ (23,374)

X

- Definition

Contract with customer liability additions.

+ References

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- Definition

Contract with customer, liability, increase (decrease) from current translation and other.

+ References

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- Definition

Contract with customer liability.

+ References

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- Definition

Contract with customer liability reclassified to accrued liability.

+ References

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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=126919976&loc=SL49130531-203044

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130549-203045

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=126919976&loc=SL49130532-203044

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- Definition

Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130549-203045

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