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Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred Revenue	$ 16,495		$ 12,739
Drug product revenue recognized	36,161	$ 60,827
Other long-term liabilities	7,063		6,440
Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty revenue recognized as drug product revenue	21,372
Drug Product Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	2,109	7,594
Drug Product Revenue [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	2,100
Drug Product Revenue [Member] | Europe [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	377	0
Drug Product Revenue [Member] | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	16,600
Accrued liabilities			57,400
Drug Product Revenue [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty revenue recognized as drug product revenue	400
Drug Product Revenue [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	1,700	9,800
Drug Product Revenue [Member] | Japan [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	1,732	7,594
Accrued liabilities	3,200		6,500
Other long-term liabilities	1,600
Drug Product Revenue [Member] | API Shipment [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized		$ 2,200
Bulk Drug Product [Member] | Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	11,200
Accrued liabilities	11,200		$ 11,200
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Accrued liabilities	16,400
Accounts payable	$ 57,500

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