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Liability Related to Sale of Future Revenues - Additional Information (Details) - USD ($)		3 Months Ended
	Nov. 04, 2022	Mar. 31, 2023	Mar. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		$ 36,161,000	$ 60,827,000
NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Effective annual interest rate related to sale of future revenues		19.64%
NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] | Minimum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Prepayment amount of 2024 to 2030	$ 80,000,000.0
NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] | Maximum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Prepayment amount of 2024 to 2030	125,000,000.0
NovaQuest Capital Management [Member] | Payment Period One [Member] | Revenue Interest Financing Agreement [Member] | Minimum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue interest payment	62,500,000
NovaQuest Capital Management [Member] | Payment Cap Date on or before December 31, 2028 [Member] | Revenue Interest Financing Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum payment cap amount	100,000,000.0
NovaQuest Capital Management [Member] | Payment Cap Date on or after January 1, 2029 [Member] | Revenue Interest Financing Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum payment cap amount	112,500,000
NovaQuest Capital Management [Member] | Payment Cap Date after January 1, 2030 [Member] | Revenue Interest Financing Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum payment cap amount	125,000,000.0
NovaQuest Capital Management [Member] | Payment Period Two [Member] | Revenue Interest Financing Agreement [Member] | Minimum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue interest payment	125,000,000.0
Product [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		$ 24,161,000	18,881,000
Product [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue interest payment	10,000,000.0
License [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		6,000,000	22,590,000
Other Revenue - Contract Manufacturing [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		3,891,000	11,762,000
Astellas Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Future revenue granted	$ 50,000,000.0
Percentage of revenue interest on global net sales	100.00%
Astellas Agreement [Member] | Maximum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue payment cap amount		125,000,000.0
Astellas Agreement [Member] | Product [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of revenue sold	22.50%
Astellas Agreement [Member] | Milestone payments [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of revenue sold	10.00%
Astellas Agreement [Member] | Milestone payments [Member] | Payment Period One [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of revenue sold	20.00%
Development Revenue [Member] | Astellas Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		1,600,000
Drug Product Revenue [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		2,109,000	$ 7,594,000
Drug Product Revenue [Member] | Astellas Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		2,100,000
Non-cash interest expense related to drug product revenue		$ 2,200,000

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