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Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2023 | Mar. 31, 2023 | Jun. 30, 2022 | Mar. 31, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Deferred Revenue | $ 7,490 |  |  |  | $ 7,490 |  | $ 12,739
Drug product revenue recognized | 44,319 |  | $ 29,806 |  | 80,480 | $ 90,633 |
Other long-term liabilities | 4,961 |  |  |  | 4,961 |  | 6,440
Astra Zeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue |  |  |  |  | 41,884 |  |
Drug Product Revenue, Net [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 14,272 |  | 1,093 |  | 16,381 | 8,687 |
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 14,300 |  |  |  | 16,400 |  |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 463 |  | 1,076 |  | 840 | 1,076 |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 24,000 |  |
Accrued liabilities |  |  |  |  |  |  | 57,400
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue | 500 |  |  |  | 800 |  |
Drug Product Revenue, Net [Member] | Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 14,400 | $ 1,700 |  | $ 9,800 |  |  |
Drug Product Revenue, Net [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 13,809 |  | $ 17 |  | 15,541 | $ 7,611 |
Accounts payable | 4,600 |  |  |  | 4,600 |  |
Accrued liabilities | 1,400 |  |  |  | 1,400 |  | $ 6,500
Other long-term liabilities | 600 |  |  |  | 600 |  |
Drug Product Revenue, Net [Member] | API Shipment [Member] | Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized | 600 |  |  | $ 2,200 |  |  |
Bulk Drug Product [Member] | Astra Zeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 11,200 |  |
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Accrued liabilities | $ 23,800 |  |  |  | $ 23,800 |  |

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