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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended				6 Months Ended
	Apr. 30, 2006	Jun. 30, 2005	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 44,319,000		$ 29,806,000		$ 80,480,000	$ 90,633,000
Deferred Revenue			7,490,000				7,490,000		$ 12,739,000
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			14,272,000		$ 1,093,000		16,381,000	$ 8,687,000
Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing							$ 0
Japan [Member] | Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			14,400,000	$ 1,700,000		$ 9,800,000
Astellas Agreement [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received		$ 172,600,000
Additional consideration based on net sales description							the low 20% range of the list price
Aggregate consideration received excluding drug product revenue			105,100,000				$ 105,100,000
Changes in revenue from changes to estimated variable consideration			0
Astellas Agreement [Member] | Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received	$ 745,000,000.0
Additional consideration based on net sales description							low 20% range
Aggregate consideration received excluding drug product revenue			685,000,000.0				$ 685,000,000.0
Transaction price, variable consideration from estimated future co-development billing							$ 2,700,000
Percentage of joint development costs committed to fund	50.00%
Transaction price and allocated to performance obligations						$ 25,000,000.0
Changes in revenue from changes to estimated variable consideration			$ 0

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The amount of additional consideration based on net sales of product as defined under a collaboration agreement.

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Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration.

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